Holding(s) in Company

Proteome Sciences Plc ("the Company")                     

                              Notifiable Interest                              

A form TR-1 containing the following information has been received by the
Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

Proteome Sciences Plc

2. Reason for the notification

Revised due to DTR rules - see section 13

3. Full name of person(s) subject to the notification obligation:

Fidelity International Limited (FIL)

4. Full name of shareholder(s) (if different from 3):

Fidelity International Limited

Fidelity Investment Services Ltd

Fidelity Investments International

5. Date of the transaction (and date on which the threshold is crossed or
reached if different):

Revised due to DTR rules

6. Date on which issuer notified:

20 March 2007 (by fax & post)

7. Threshold(s) that is/are crossed or reached:

N/A

8. Notified details:

A: Voting rights attached to shares

Class/type of Situation previous   Resulting situation after the triggering    
shares        to Triggering        transaction                                 
              transaction                                                      
if possible                        Notification required under DTR transitional
using ISIN                         provision 7                                 
CODE                                                                           
              Number of Number of  Number  Number of voting   % of voting      
              Shares    Voting     of      rights             rights           
                        Rights     shares                                      
                                                                               
                                   Direct  Direct  Indirect   Direct  Indirect 
                                                                               
Ordinary      6,929,879 6,929,879                  6,929,879          5.28%    
shares                                                                         
                                                                               
GB0003104196                                                                   

B: Financial Instruments

Resulting situation after the triggering transaction                         
                                                                             
Type of       Expiration     Exercise/      Number of voting  % of voting    
financial     date           Conversion     rights that may   rights         
instrument                   Period/ Date   be acquired if                   
                                            the instrument is                
                                            exercised/                       
                                            converted                        
                                                                             
NIL                                                                          

Total (A+B)

Number of voting rights                % of voting rights                    
                                                                             
6,929,879                              5.28%                                 

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

Fidelity International Limited is the parent holding company for various direct
and indirect subsidiaries, including Fidelity Investment Services Ltd and
Fidelity Investments International.

10. Name of the Proxy holder:

Fidelity International Limited

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

As discussed with the FSA, prior to the implementation of the EU Transparency
Directive, we aggregated the interests in shares of FMR Corp (FMR) and Fidelity
International Limited (FIL). According to the new DTR rules we are now
reporting the indirect holdings of FMR and FIL separately. A separate
notification is being submitted for FMR Corp. Please note these holdings are
correct as of close of business 16 March 2007.

14. Contact name:

Christopher Pearce or James Malthouse 01932 865065

Proteome Sciences PLC

Thilo Hoffmann 020 7426 9000

Teather & Greenwood Limited

15. Contact telephone number:


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