Holding(s) in Company

Proteome Sciences Plc ("the Company")                     

                              Notifiable Interest                              

A form TR-1 containing the following information has been received by the
Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

Proteome Sciences Plc

2. Reason for the notification

An acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

Credit Agricole Cheuvreux International Ltd

4. Full name of shareholder(s) (if different from 3):

5. Date of the transaction (and date on which the threshold is crossed or
reached if different):

15 March 2007

6. Date on which issuer notified:

19 March 2007 (by fax & post)

7. Threshold(s) that is/are crossed or reached:

7%

8. Notified details:

A: Voting rights attached to shares

Class/type   Situation previous  Resulting situation after the triggering      
of shares    to Triggering       transaction                                   
             transaction                                                       
if possible                      Notification required under DTR transitional  
using ISIN                       provision 7                                   
CODE                                                                           
             Number of Number of Number of Number of voting    % of voting     
             Shares    Voting    shares    rights              rights          
                       Rights                                                  
                                 Direct    Direct    Indirect  Direct  Indirect
                                                                               
Ordinary     9,134,552 9,134,552 9,234,552 9,234,552 N/A       7.02%   N/A     
shares                                                                         
                                                                               
GB0003104196                                                                   

B: Financial Instruments

Resulting situation after the triggering transaction                         
                                                                             
Type of       Expiration     Exercise/      Number of voting  % of voting    
financial     date           Conversion     rights that may   rights         
instrument                   Period/ Date   be acquired if                   
                                            the instrument is                
                                            exercised/                       
                                            converted                        
                                                                             
NIL                                                                          

Total (A+B)

Number of voting rights                % of voting rights                    
                                                                             
9,234,552                              7.02%                                 

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

SAS Rue La Boetie

Credit Agricole SA

Calyon SA

Credit Agricole Cheuvreux SA 9,234,552 7,02%

10. Name of the Proxy holder:

N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

N/A

14. Contact name:

Christopher Pearce or James Malthouse 01932 865065

Proteome Sciences PLC

Thilo Hoffmann 020 7426 9000

Teather & Greenwood Limited

15. Contact telephone number: