Holding(s) in Company

Proteome Sciences Plc ("the Company")

27 July 2006

Notifiable Interest

The Company received notification on 27 July 2006 from Fidelity International
that FMR Corp. and its direct and indirect subsidiaries, Fidelity International
Limited and its direct and indirect subsidiaries and Mr Edward C. Johnson 3rd
(a principal shareholder of FMR Corp. and Fidelity International), have a
notifiable interest in the ordinary shares of the Company of 9,255,721 shares,
being 7.04% of the current issued ordinary share capital of the Company.