Holding(s) in Company

Proteome Sciences plc ('the Company')                     

Proteome Sciences plc was advised on the 6 April 2005 that as at that date FMR
Corp. and its direct & indirect subsidiaries and Fidelity International Limited
and its direct and indirect subsidiaries and Mr Edward C. Johnson 3rd (A
principal shareholder of FMR Corp / Fidelity International Limited) have a
notifiable interest in 16,706,699 ordinary shares, representing 13.65% of the
companies issued ordinary share capital.