Holding(s) in Company

Proteome Sciences plc ('the Company')                     

Proteome Sciences plc was advised on the 31st January 2005 that as at that date
FMR Corp. and its direct & indirect subsidiaries and Fidelity International
Limited and its direct and indirect subsidiaries and Mr Edward C. Johnson 3rd
(A principal shareholder of FMR Corp / Fidelity International Limited) have a
notifiable interest in 8,527,741 ordinary shares, representing 6.96% of the
companies issued ordinary share capital.