Holding(s) in Company

Proteome Sciences PLC ("the Company")                     

                              Notifiable Interest                              

                                                                               

A form TR-1 containing the following information has been received by the
Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

Proteome Sciences

2. Reason for the notification

An acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

MF Global UK Limited

4. Full name of shareholder(s) (if different from 3):

N/A

5. Date of the transaction (and date on which the threshold is crossed or
reached if different):

12/02/08

6. Date on which issuer notified:

13/02/08

7. Threshold(s) that is/are crossed or reached:

2

8. Notified details:

3.00

A: Voting rights attached to shares

Class/type   Situation previous to Resulting situation after the triggering    
of shares    Triggering            transaction                                 
             transaction                                                       
if possible                        Notification required under DTR transitional
using ISIN                         provision 7                                 
CODE                                                                           
             Number of Number of   Number of Number of voting   % of voting    
             Shares    Voting      shares    rights             rights         
                       Rights                                                  
                                                                               
                                                                               
                                   Direct    Direct    Indirect Direct Indirect
                                                                               
                                                                               
                                                                               
ISIN                                                                           
                                                                               
GB0003104196 7,880,616  7,880,616  3,932,381 3,932,381          2.99%          
                                                                               

B: Financial Instruments

Resulting situation after the triggering transaction                           
                                                                               
                                                                               
                                                                               
Type of     Expiration Exercise/     Number of voting rights that may   % of   
financial   date       Conversion    be acquired if the instrument is   voting 
instrument             Period/ Date  exercised/ converted               rights 
                                                                               
                                                                               
                                                                               
N/A         N/A        N/A           N/A                                N/A    
                                                                               

Total

Number of voting rights % of voting rights
                                          
                                          
                                          
                                          
                                          
       3,932,381              2.99%       
                                          

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

N/A

10. Name of the Proxy holder:

N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

N/A

14. Contact details:

[e-mail]