Holding(s) in Company

Proteome Sciences PLC ("the Company")                     

                              Notifiable Interest                              

                                                                               

A form TR-1 containing the following information has been received by the
Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

Proteome Sciences PLC

2. Reason for the notification

An acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

MF Global UK Limited

4. Full name of shareholder(s) (if different from 3):

N/A

5. Date of the transaction (and date on which the threshold is crossed or
reached if different):

22/01/08

6. Date on which issuer notified:

23/01/08

7. Threshold(s) that is/are crossed or reached:

5

8. Notified details:

5.98

A: Voting rights attached to shares

Class/type   Situation previous  Resulting situation after the triggering       
of shares    to Triggering       transaction                                    
             transaction                                                        
if possible                      Notification required under DTR transitional   
using ISIN                       provision 7                                    
CODE                                                                            
             Number of Number of Number of Number of voting   % of voting rights
             Shares    Voting    shares    rights                               
                       Rights                                                   
                                                                                
                                                                                
                                 Direct    Direct    Indirect Direct    Indirect
                                                                                
                                                                                
                                                                                
ISIN                                                                            
                                                                                
GB0003104196 7,903,116 7,903,116 7,885,616 7,855,616          7,855,616         
                                                                                

B: Financial Instruments

Resulting situation after the triggering transaction                     
                                                                         
                                                                         
                                                                         
Type of      Expiration    Exercise/     Number of voting  % of voting   
financial    date          Conversion    rights that may   rights        
instrument                 Period/ Date  be acquired if                  
                                         the instrument is               
                                         exercised/                      
                                         converted                       
                                                                         
                                                                         
                                                                         
N/A          N/A           N/A           N/A               N/A           
                                                                         

Total (A+B)

Number of voting rights             % of voting rights                 
                                                                       
                                                                       
                                                                       
                                                                       
                                                                       
             7,855,616                             5.98%               
                                                                       

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

N/A

10. Name of the Proxy holder:

N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

N/A

14. Contact details:

[e-mail]