Holding(s) in Company

Proteome Sciences PLC ("the Company")                     

                              Notifiable Interest                              

A form TR-1 containing the following information has been received by the
Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

Proteome Sciences PLC

2. Reason for the notification

An acquisition of voting rights

3. Full name of person(s) subject to the notification obligation:

Cubana Investments Limited

4. Full name of shareholder(s) (if different from 3):

5. Date of the transaction (and date on which the threshold is crossed or
reached if different):

01 August 2008

6. Date on which issuer notified:

05 August 2008

7. Threshold(s) that is/are crossed or reached:

8.00%

8. Notified details:

A: Voting rights attached to shares

Class/type  Situation previous to Resulting situation after the triggering      
of shares   Triggering            transaction                                   
            transaction                                                         
if possible                       Notification required under DTR transitional  
using ISIN                        provision 7                                   
CODE                                                                            
            Number of  Number of  Number of  Number of voting    % of voting    
            Shares     Voting     shares     rights              rights         
                       Rights                                                   
                                  Direct     Direct     Indirect Direct Indirect
                                                                                
GB003104196 10,617,248 10,617,248 10,987,468 10,987,468          8.28%          

B: Financial Instruments

Resulting situation after the triggering transaction                         
                                                                             
Type of       Expiration     Exercise/      Number of voting  % of voting    
financial     date           Conversion     rights that may   rights         
instrument                   Period/ Date   be acquired if                   
                                            the instrument is                
                                            exercised/                       
                                            converted                        
                                                                             

Total (A+B)

Number of voting rights                % of voting rights                    
                                                                             
10,987,468                             8.28%                                 

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:


10. Name of the Proxy holder:


11. Number of voting rights proxy holder will cease to hold:


12. Date on which proxy holder will cease to hold voting rights:


13. Additional information:


14. Contact name:

James Malthouse

15. Contact telephone number:

[phone]