Holding(s) in Company

TR-1: NOTIFICATION OF MAJOR INTERESTS IN SHARES                                
                                                                               
1. Identity of the issuer or the underlying     Proteome Sciences PLC           
issuer of existing shares to which voting                                      
rights are attached:                                                           
                                                                               
2. Reason for the notification (please tick the appropriate box or             
boxes)                                                                         
                                                                               
An acquisition or disposal of voting rights             X    
                                                                               
An acquisition or disposal of financial instruments which may result           
in the acquisition of shares already issued to which voting rights are         
attached                                                                       
                                                                               
An event changing the breakdown of voting rights                               
                                                                               
Other (please specify): Confirmation of our holding                            
                                                                               
3. Full name of person(s) subject to the        Deutsche Bank AG               
notification obligation:                                                       
                                                                               
4. Full name of shareholder(s) (if different                                   
from 3.):                                                                      
                                                                               
5. Date of the transaction (and date on which   17 July 2008                   
the threshold is crossed or reached if                                         
different):                                                                    
                                                                               
6. Date on which issuer notified:               21 June 2008                   
                                                                               
7. Threshold(s) that is/are crossed or reached: 3%                             
                                                                               
8. Notified details:                                                           

A: Voting rights attached to shares                                           
                                                                              
Class/type  Situation       Resulting situation after the triggering          
of shares   previous to the transaction                                       
            Triggering                                                        
if possible transaction                                                       
using the                                                                     
ISIN CODE                                                                     
                                                                              
             Number of    Number of   Number of Number of voting   % of voting rights          
             Shares       Voting      shares    rights                                         
                          Rights                                                             

                                      Direct    Direct    Indirect Direct   Indirect 
                                                                               
GB0003104196 4,019,397    4,019,397   Below 3%                     Below 3%
                                                                              
                                                                                

B: Financial Instruments                                                       
                                                                               
Resulting situation after the triggering transaction                           
                                                                               
Type of         Expiration  Exercise/          Number of voting    % of voting 
financial       date        Conversion Period/ rights that may be  rights      
instrument                  Date               acquired if the                 
                                               instrument is                   
                                               exercised/                      
                                               converted                       
                                                                               

Total (A+B)                                                                    
                                                                               
Number of voting rights                % of voting rights                      
                                                                               
Below 3%                               Below 3%                                

9. Chain of controlled undertakings through which the voting rights and/or the 
financial instruments are effectively held, if applicable:                     
                                                                               

Proxy Voting:                                                                  
                                                                               
10. Name of the proxy holder:                                                  
                                                                               
11. Number of voting rights proxy holder will cease                            
to hold:                                                                       
                                                                               
12. Date on which proxy holder will cease to hold                              
voting rights:                                                                 
                                                                               
13. Additional information                                                     
                                                                               
14 Contact name:                        James Malthouse                        
                                                                               
15. Contact telephone name:             [phone]