Holding(s) in Company

Proteome Sciences plc ('the Company')                     

Proteome Sciences plc was advised on the 2nd September 2005 that as at that
date FMR Corp. and its direct & indirect subsidiaries and Fidelity
International Limited and its direct and indirect subsidiaries and Mr Edward C.
Johnson 3rd (A principal shareholder of FMR Corp / Fidelity International
Limited) have a notifiable interest in 15,422,639 ordinary shares, representing
11.73% of the companies issued ordinary share capital.