Correction : Holding(s) in Company

This announcement replaces the announcement released 26 February at 09.00. In
the announcement released at 09.00, the Sanofi-Aventis interest holdings was
incorrectly stated as having crossed the 9% threshold. The correct threshold
crossed is 10%



For filings with the FSA include the annex  
For filings with issuer exclude the annex   

TR-1: Notifications of Major Interests in Shares                               

1. Identity of the issuer or the underlying issuer of existing                 
shares to which voting rights are attached:                                    
                                                                               
Proteome Sciences plc                                                          
                                                                               
2. Reason for notification                                        [Yes/No]     
                                                                               
An acquisition or disposal of voting rights                         Yes        
                                                                               
An acquisition or disposal of financial instruments which            No        
may result in the                                                              
acquisition of shares already issued to which voting rights                    
are attached                                                                   
                                                                               
An event changing the breakdown of voting rights                     No        
                                                                               
Other (please specify):                                              No        
                                                                               
3. Full name of person(s) subject to     Sanofi-Aventis Deutschland GmbH       
notification                                                                   
obligation:                                                                    
                                                                               
4. Full name of shareholder(s) (if                                             
different from 3):                                                             
                                                                               
5. Date of transaction (and date on      24 February 2009                      
which the                                                                      
threshold is crossed or reached if                                             
different):                                                                    
                                                                               
6. Date on which issuer notified:        25 February 2009                      
                                                                               
7. Threshold(s) that is/are crossed or   10.00%                                
reached:                                                                       

8: Notified Details                                                            
                                                                               
A: Voting rights attached to shares                                            

Class/type of Situation previous to            Resulting situation after           
shares           the triggering               the triggering transaction           
                   transaction                                                     
                                                                                   
If possible   Number of  Number of  Number of       Number of       Percentage of  
use             shares     voting     shares      voting rights     voting rights  
ISIN code                  rights                                                  
                                                                                   
                                                 Direct   Indirect Direct  Indirect
                                                                                   
GB003104196   13,663,380 13,663,380 12,286,187 12,286,187            9.25%         
                                                                                   

B: Financial Instruments                                                       
                                                                               
Resulting situation after the triggering transaction                           

Type of          Expiration      Exercise/      No. of voting    Percentage of 
financial           date        conversion    rights that may be voting rights 
instrument                      period/date    acquired (if the                
                                                  instrument                   
                                                  exercised/                   
                                                  converted)                   
                                                                               

Total (A+B)                                                                    

Number of voting rights                 Percentage of voting rights            
                                                                               
12,286,187                              9.25%                                  

9. Chain of controlled undertakings through which the voting rights and /or the
financial instruments are effectively held, if applicable:                     
                                                                               

Proxy Voting:                                                                  
                                                                               
10. Name of proxy holder:                                                      
                                                                               
11. Number of voting rights proxy                                              
holder will cease to hold:                                                     
                                                                               
12. Date on which proxy holder will                                            
cease to hold voting rights:                                                   

13. Additional information:                                                    
                                                                               
14 Contact name:                    James Malthouse                            
                                                                               
15. Contact telephone name:         [phone]                            


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