Holding(s) in Company

For filings with the FSA include the annex                                              
For filings with issuer exclude the annex                                               
                                                                                       
                                                                                        
TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi                                         
                                                                                        
                                                                                        
                                                                                        
1. Identity of the issuer or the underlying issuer                    Crystal Amber Fund
of existing shares to which voting rights are                                        Ltd
attached:ii                                                                             
                                                                                        
2 Reason for the notification (please tick the appropriate box or boxes):               
                                                                                        
An acquisition or disposal of voting rights                                             
                                                                                        
An acquisition or disposal of qualifying financial instruments which may result         
in the acquisition of shares already issued to which voting rights are attached         
                                                                                        
An acquisition or disposal of instruments with similar economic effect to               
qualifying financial instruments                                                        
                                                                                        
An event changing the breakdown of voting rights                                        
                                                                                        
Other (please specify):        Corrected, using post-placing SII number of  95,941,800 X
                                                                                        
3. Full name of person(s) subject to the              Woodford Investment Management LLP
notification obligation:iii                                                   (Woodford)
                                                                                        
4. Full name of shareholder(s)                                       Clients of Woodford
 (if different from 3.):iv                                                              
                                                                                        
5. Date of the transaction and date on                                                  
which the threshold is crossed or                                                23.1.15
reached: v                                                                              
                                                                                        
6. Date on which issuer notified:                                                27.1.15
                                                                                        
7. Threshold(s) that is/are crossed or                                            5, 10%
reached: vi, vii                                                                        
                                                                                        


 

8. Notified details:                                                                                        
                                                                                                            
A: Voting rights attached to shares viii, ix                                                                
                                                                                                            
Class/type   Situation previous             Resulting situation after the triggering transaction            
of           to the triggering                                                                              
shares       transaction                                                                                    
                                                                                                            
                                                                                                            
if possible  Number          Number         Number           Number of voting         % of  voting rights x 
using        of              of             of shares        rights                                         
the ISIN     Shares          Voting                                                                         
CODE                         Rights                                                                         
                                            Direct           Direct xi  Indirect xii  Direct  Indirect      
                                                                                                            
                                                                                                            
GG00B1Z2SL48        0              0           9,646,302     9,646,302                 10.1%                
                                                                                                            
                                                                                                            
                                                                                                            
B: Qualifying Financial Instruments                                                                         
                                                                                                            
Resulting situation after the triggering transaction                                                        
                                                                                                            
Type of financial  Expiration      Exercise/                   Number of voting              % of voting    
instrument         date xiii       Conversion Period xiv       rights that may be            rights         
                                                               acquired if the                              
                                                               instrument is                                
                                                               exercised/ converted.                        
                                                                                                            
                                                                                                            
                                                                                                            
                                                                                                            
                                                                                                            
C: Financial Instruments with similar economic effect to Qualifying Financial                               
Instruments xv, xvi                                                                                         
                                                                                                            
Resulting situation after the triggering transaction                                                        
                                                                                                            
Type of       Exercise price Expiration    Exercise/         Number of voting rights   % of voting rights   
financial                    date xvii     Conversion period instrument refers to      xix, xx              
instrument                                 xviii                                                            
                                                                                                            
                                                                                                            
                                                                                       Nominal Delta        
                                                                                                            
                                                                                                            
                                                                                                            
                                                                                                            
                                                                                                            
Total (A+B+C)                                                                                               
                                                                                                            
Number of voting rights                            Percentage of voting rights                              
                                                                                                            
9,646,302                                          10.1%                                                    
                                                                                                            


 

9. Chain of controlled undertakings through which the voting rights and/or the          
financial instruments are effectively held, if applicable: xxi                          
                                                                                        
                                                                                        
                                                                                        
Woodford Investment Management LLP as Investment Manager                                
                                                                                        
                                                                                        
                                                                                        
                                                                                        
                                                                                        
Proxy Voting:                                                                           
                                                                                        
10. Name of the proxy holder:                                                           
                                                                                        
11. Number of voting rights proxy holder will cease                                     
to hold:                                                                                
                                                                                        
12. Date on which proxy holder will cease to hold                                       
voting rights:                                                                          
                                                                                        
                                                                                        
                                                                                        
                                                                                        
13. Additional information:                                                             
                                                                                        
14. Contact name:                                                               Jon Webb
                                                                                        
15. Contact telephone number:                                               01865 809023