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Creon Corporation plc (AMED)

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Monday 18 August, 2008

Creon Corporation plc

TR-1: Notifications of Major Interests in Shares

TR-1: Notifications of Major Interests in Shares                               
1. Identity of the issuer or the underlying     
issuer of existing shares to which voting                                      
rights are attached:                                   Creon Corporation plc                                        
2. Reason for notification (yes/no)                                            
An acquisition or disposal of voting rights                             Yes    
An acquisition or disposal of financial instruments which may result     No    
in the acquisition of shares already issued to which voting rights             
are attached                                                                   
An event changing the breakdown of voting rights                        Yes    
Other (please specify):______________                                          
3. Full name of person(s) subject to    Equity Pre-IPO Investments Limited     
notification obligation:                                                       
4. Full name of shareholder(s) (if                                             
different from 3):                                                             
5. Date of transaction (and date on     1 August 2008                          
which the threshold is crossed or                                              
reached if different):                                                         
6. Date on which issuer notified:       1 August 2008                          
7. Threshold(s) that is/are crossed or  3%                                     

8: Notified Details                                                            
A: Voting rights attached to shares                                            
Class/type  Situation         Resulting situation after the triggering         
of shares   previous to the   transaction                                      
If possible transaction                                                        
use ISIN                                                                       

Number of    Number  Number of     Number of voting  Percentage of    
shares       of      shares        rights            voting rights    
             rights                Direct  Indirect  Direct  Indirect 
Ordinary      Below  Below 378,097 378,097     0      3.14%      0    
Shares         3%     3%                                              

B: Financial Instruments                                                       
Resulting situation after the triggering transaction                           
Type of        Expiration     Exercise/       No. of voting      Percentage of 
financial      date           conversion      rights that may be voting rights 
instrument                    period/date     acquired (if the                 

Total (A+B)                                                                    
Number of voting rights                 Percentage of voting rights            
                378,097                                  3.14%                 

9. Chain of controlled undertakings through which the voting rights and /or the
financial instruments are effectively held, if applicable:                     

Proxy Voting:                                                                  
10. Name of proxy holder:                                                      
11. Number of voting rights proxy                                              
holder will cease to hold:                                                     
12. Date on which proxy holder will                                            
cease to hold voting rights:                                                   

13. Additional information:                                                    
14 Contact name:                        Martin Shires                          
15. Contact telephone name:             +44 (0)1 481 751 000                   

For further information please contact:

Creon Corporation Plc Jonathan Freeman +44 (0)20 7752 0215

Daniel Stewart & Company Plc Oliver Rigby +44 (0)207 776 6550

GTH Media Relations Toby Hall +44 (0)20 7153 8039

Christian Pickel +44 (0)20 7153 8036


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