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The data that we collect from you may be transferred to, and stored at, a destination outside the European Economic Area (“EEA”). It may be processed by staff operating outside the EEA who work for us or for one of our suppliers. Such staff may be engaged in, amongst other things, the provision of support services. By submitting your personal data, you agree to this transfer, storing and processing. We will take all steps reasonably necessary, including the use of encryption, to ensure that your data is treated securely and in accordance with this privacy policy.

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Verseon Corporation (VSN)

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Wednesday 15 November, 2017

Verseon Corporation

Verseon presents second anticoagulant candidate

RNS Number : 3822W
Verseon Corporation
15 November 2017
 

Press release                                                                                                                                     November 15, 2017

Verseon Corporation

("Verseon" or the "Company")

Second anticoagulation candidate for clinical trials presented at AHA 2017

Fremont, Calif.-Verseon, a technology-based pharmaceutical company employing a computer-driven platform to develop a diverse drug pipeline, presented a second development candidate for clinical trials from its anticoagulation program at the American Heart Association's (AHA) Scientific Sessions 2017, yesterday. VE-2851 shows excellent efficacy paired with low bleeding risk in preclinical testing and is expected to enter clinical trials in 2018.

 

The candidate potently inhibits thrombin and is highly selective against a panel of related serine proteases. VE-2851 also shows pharmacokinetics suitable for oral dosing and was well tolerated in a 14-day dose-range finding study. In preclinical efficacy models such as the arteriovenous shunt thrombosis model, the compound displayed comparable efficacy to marketed anticoagulants. Similar to Verseon's first development candidate VE-1902, which is expected to enter phase I trials in early 2018, VE-2851 likewise potently inhibits thrombosis, but does not disrupt platelet function. It shows 30-40‑fold weaker inhibition of thrombin-mediated platelet activation in vitro and allows up to 5-fold higher maximum platelet activation in vivo compared to current NOACs. This distinguishing feature of Verseon's anticoagulants provides a biological rationale for their improved hemostatic control and the resulting lower bleeding risk observed in preclinical bleeding time tests.

 

"We are excited to have two drug candidates heading to the clinic in 2018," said Dr. Anirban Datta, Verseon's Director of Discovery Biology, who presented the results at the AHA conference. "Both development candidates act as potent anticoagulants without disrupting platelet function. This may allow them to become the first anticoagulants suitable for long-term combination therapy with antiplatelet drugs, achieving a significantly reduced risk of both major adverse cardiovascular events and bleeding." 

 

The full AHA abstract is available on the conference website and will be published in Circulation. Dr. Datta's presentation will also be featured in Thrombosis.TV, a leading destination for venous and arterial thrombosis education, news, and expert opinion.

 



 

About Verseon's anticoagulation program

Verseon's potent, highly selective oral direct thrombin inhibitors have shown excellent efficacy in multiple preclinical studies, but do not disrupt platelet function. This unique feature could explain the low bleeding risk of these precision anticoagulants and makes them excellent candidates for use in long-term combination anticoagulant-antiplatelet therapy. Two development candidates are expected to enter clinical trials in 2018, one of which has also demonstrated very low renal clearance, a highly desirable property for patients with impaired kidney function.

 

About Verseon

Verseon Corporation (www.verseon.com, AIM: VSN) is a technology-based pharmaceutical company that combines a proprietary, computational drug discovery platform with a comprehensive in-house chemistry and biology workflow to develop novel therapeutics that are unlikely to be found using conventional methods. The Company is applying its platform to a growing drug pipeline and currently has four active drug programs in the areas of anticoagulation, diabetic macular edema, hereditary angioedema, and oncology. The anticoagulation program is scheduled to enter phase I clinical trials in 2018.

-Ends-

For further information, please contact

Verseon Corporation

www.verseon.com

Tina Schlafly

+1 (510) 225 9000



Cenkos Securities (NOMAD and Joint Broker)


Neil McDonald / Beth McKiernan

 +44 (0) 20 7397 8900



Cantor Fitzgerald Europe (Joint Broker) 


Marc Milmo / Phil Davies / Callum Butterfield

+44 (0) 20 7894 7000



Mirabaud Securities LLP (Joint Broker)


Peter Krens

+44 (0) 20 7321 2508

 

For financial and business media enquiries, please contact

Buchanan Communications Ltd (PR Advisers)


Henry Harrison-Topham / Jamie Hooper

+44 (0) 20 7466 5000

 

For trade and pharma media enquiries, please contact

Vane Percy & Roberts


Simon Vane Percy

+44 (0) 1737 821 890

 

Forward-Looking Statements

This press release contains forward-looking statements, which are generally statements that are not historical facts. Forward-looking statements can be identified by the words "expects," "anticipates," "believes," "intends," "estimates," "plans," "will," "outlook," and similar expressions. Forward-looking statements are based on management's current plans, estimates, assumptions, and projections, and speak only as of the date they are made. We undertake no obligation to update any forward-looking statement in light of new information or future events, except as otherwise required by law. Forward-looking statements involve inherent risks and uncertainties, most of which are difficult to predict and are generally beyond our control. Actual results or outcomes may differ materially from those implied by the forward-looking statements as a result of the impact of a number of factors.

 


This information is provided by RNS
The company news service from the London Stock Exchange
 
END
 
 
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