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Protherics PLC (PTI)

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Friday 20 January, 2006

Protherics PLC

Interest in Shares

Protherics PLC
20 January 2006


                                 PROTHERICS PLC

                     NOTIFICATION OF MAJOR INTERESTS IN SHARES

20 January 2005: Protherics PLC (the "Company"), the biopharmaceutical company
focused on critical care and oncology, received notification today from
Perpetual Income & Growth Investment Trust plc on behalf of INVESCO Asset
Management Limited that Perpetual Income & Growth Investment Trust plc is the
beneficial owner of 10,115,137 ordinary shares representing 3.92% of the issued
share capital of the Company.

This notification follows an increase in the Company's issued share capital to
258,328,129 ordinary shares.

For further information contact:

Protherics PLC                                  +44 (0) 20 7246 9950
Julie Vickers, Company Secretary                +44 (0) 1928 518010
Nick Staples, Corporate Affairs                 +44 (0) 7919 480510

Financial Dynamics                              +44 (0) 20 7831 3113
Ben Atwell/David Yates


                      This information is provided by RNS
            The company news service from the London Stock Exchange

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