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Protherics PLC (PTI)

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Monday 12 June, 2006

Protherics PLC

Holding(s) in Company

Protherics PLC
12 June 2006

                                 PROTHERICS PLC

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


12 June 2006: Protherics PLC ("the "Company"), the international
biopharmaceutical company focused on critical care and oncology, received
notification on 12 June 2006 on behalf of Perpetual Income & Growth Investment
Trust plc ("Perpetual") that, following the purchase of 729,934 Ordinary Shares
of 2p each in the Company ("Ordinary Shares") on 8 June 2006, Perpetual is the
beneficial owner of 10,749,436 Ordinary Shares, representing 4.13% of the issued
share capital of the Company.  The shares which are the subject of this
notification are registered in the name of Vidacos Nominees Limited.



The Company's current issued share capital is 260,295,464 ordinary shares.



ENDS



For further information contact:

Protherics PLC                                  +44 (0) 20 7246 9950
Julie Vickers, Company Secretary                +44 (0) 1928 518010
Nick Staples, Corporate Affairs                 +44 (0) 7919 480510 (mobile)


Financial Dynamics                              +44 (0) 20 7831 3113
Ben Atwell/David Yates








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