Grant of share options and Directors' dealings

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Notification of a Transaction pursuant to Article 19(1) of Regulation (EU) No. 596/2014
1	Details of the person discharging managerial responsibilities/person closely associated
a.	Name	Steve Medlicott
2	Reason for notification
a.	Position/Status	Director
b.	Initial notification/ Amendment	Initial Notification
3	Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor
a.	Name	e-Therapeutics plc
b.	LEI	N/A
4	Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted
a.	Description of the financial instrument, type of instrument Identification Code	Ordinary shares of 0.1p each ISIN: GB00B2823H99
b.	Nature of the transaction	Grant of options to subscribe for ordinary shares
c.	Price(s) and volume(s)
			Exercise price(s)	Volume(s)
			£0.1676	666,666
			£0.2095	666,667
			£0.2514	666,667

d.	Aggregated information- Aggregated Volume - Price	Volume: 2,000,000 options over ordinary shares Price: N/A
e.	Date of the transaction	23 November 2016
f.	Place of the transaction	London Stock Exchange

Notification of a Transaction pursuant to Article 19(1) of Regulation (EU) No. 596/2014
1	Details of the person discharging managerial responsibilities/person closely associated
a.	Name	Sean Nicolson
2	Reason for notification
a.	Position/Status	Director
b.	Initial notification/ Amendment	Initial Notification
3	Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor
a.	Name	e-Therapeutics plc
b.	LEI	N/A
4	Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted
a.	Description of the financial instrument, type of instrument Identification Code	Ordinary shares of 0.1p each ISIN: GB00B2823H99
b.	Nature of the transaction	Grant of options to subscribe for ordinary shares
c.	Price(s) and volume(s)
			Exercise Price(s)	Volume(s)
			£0.1676	250,000
			£0.2095	250,000
			£0.2514	250,000

d.	Aggregated information- Aggregated Volume - Price	Volume: 750,000 Price: N/A
e.	Date of the transaction	23 November 2016
f.	Place of the transaction	London Stock Exchange

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