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Creon Corporation plc (AMED)

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Friday 08 May, 2009

Creon Corporation plc

TR-1: Notifications of Major Interests in Shares


                             Creon Corporation Plc                             

                      ("Creon", "Company" or the "Group")                      

TR-1: Notifications of Major Interests in Shares                               

1. Identity of the issuer or the underlying       Creon Corporation Ord GBP    
issuer of existing shares to which voting rights  0.01p                        
are attached:                                                                  
                                                                               
2. Reason for notification (yes/no)                                            
                                                                               
An acquisition or disposal of voting rights                         Yes        
                                                                               
An acquisition or disposal of financial instruments which may                  
result in the acquisition of shares already issued to which voting             
rights are attached                                                            
                                                                               
An event changing the breakdown of voting rights                               
                                                                               
Other (please specify):______________                                          
                                                                               
3. Full name of person(s) subject to       The Royal Bank of Scotland Group Plc
notification obligation:                                                       
                                                                               
4. Full name of shareholder(s) (if         Adam & Co (Nominees) Ltd A/C AIM    
different from 3):                                                             
                                                                               
5. Date of transaction (and date on which  1/5/2009                            
the threshold is crossed or reached if                                         
different):                                                                    
                                                                               
6. Date on which issuer notified:          5/5/2009                            
                                                                               
7. Threshold(s) that is/are crossed or     5%                                  
reached:                                                                       
                                                                               
8: Notified Details                                                            
                                                                               
A: Voting rights attached to shares                                            
                                                                               
Class/type   Situation previous  Resulting situation after the triggering      
of shares    to the triggering   transaction                                   
             transaction                                                       
If possible                                                                    
use ISIN                                                                       
code                                                                           
                                                                               

Number of    Number of  Number of  Number of       Percentage of voting 
shares       voting     shares     voting rights   rights               
             rights                                                     
                                   Direct Indirect Direct      Indirect 
                                                                        
Ordinary     11,162,734 11,162,734 0    0          3,962,734   9.00%    
Shares                                                                  
                                                                        
GB00B02TDY97                                                            

B: Financial Instruments                                                       
                                                                               
Resulting situation after the triggering transaction                           
                                                                               
Type of        Expiration     Exercise/       No. of voting      Percentage of 
financial      date           conversion      rights that may be voting rights 
instrument                    period/date     acquired (if the                 
                                              instrument                       
                                              exercised/                       
                                              converted)                       
                                                                               

Total (A+B)                                                                    
                                                                               
Number of voting rights                 Percentage of voting rights            
                                                                               
3,962,734                               9.00%                                  

9. Chain of controlled undertakings through which the voting rights and /or the
financial instruments are effectively held, if applicable:                     
                                                                               
The Royal Bank of Scotland Group Plc (9.00%)                                   
                                                                               
The Royal Bank of Scotland Plc (9.00%)                                         
                                                                               
Adam & Co Group Plc (9.00%)                                                    
                                                                               
Adam & Co Investment Management Ltd (9.00%)                                    

Proxy Voting:                                                                  
                                                                               
10. Name of proxy holder:                                                      
                                                                               
11. Number of voting rights proxy                                              
holder will cease to hold:                                                     
                                                                               
12. Date on which proxy holder will                                            
cease to hold voting rights:                                                   

13. Additional information:             This notification is based upon the    
                                        Voting Rights figure of 43,990,545     
                                        obtained from your Regulatory          
                                        Announcement dated 27th January 2009.  
                                                                               
14 Contact name:                        Richard Hopkins                        
                                                                               
15. Contact telephone number:           020 7714 4459                          

For further information please contact:

Creon Corporation Plc Jonathan Freeman +44 (0)20 7752 0215

Daniel Stewart & Company Plc Oliver Rigby +44 (0)207 776 6550

GTH Media Relations Toby Hall +44 (0)20 7153 8039

Christian Pickel +44 (0)20 7153 8036


                                                                                                                                                        

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