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Creon Corporation plc (AMED)

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Friday 06 February, 2009

Creon Corporation plc

TR-1: Notifications of Major Interests in Shares


TR-1: Notifications of Major Interests in Shares                               

1. Identity of the issuer or the underlying       
issuer of existing shares to which voting rights                               
are attached: Creon Corporation Ord GBP 0.01p                    
                                                                               
2. Reason for notification (yes/no)                                            
                                                                               
An acquisition or disposal of voting rights: Yes        
                                                                               
An acquisition or disposal of financial instruments which may                  
result in the acquisition of shares already issued to which voting             
rights are attached                                                            
                                                                               
An event changing the breakdown of voting rights                               
                                                                               
Other (please specify):______________                                          
                                                                               
3. Full name of person(s) subject to notification obligation:  The Royal Bank of Scotland Group plc
                                                     
                                                                               
4. Full name of shareholder(s)(if different from 3): Adam & Co (Nominees) Ltd A/C AIM                                                                
                                                                               
5. Date of transaction (and date on which  
the threshold is crossed or reached if                                         
different): 30/01/2009                                                                                           
                                                                               
6. Date on which issuer notified: 02/02/2009                          
                                                                               
7. Threshold(s) that is/are crossed or reached:20%                                                                                                      
                                                                               
8: Notified Details                                                            
                                                                               
A: Voting rights attached to shares                                            
                                                                               
Class/type   Situation         Resulting situation after the triggering        
of shares    previous to the   transaction                                     
             triggering                                                        
If possible  transaction                                                       
use ISIN                                                                       
code                                                                           
                                                                               
                                                                               

Number of    Number Number Number of       Percentage of voting  
shares       of     of     voting rights   rights                
             voting shares                                       
             rights                                              
                           Direct Indirect Direct       Indirect 
                                                                 
Ordinary     0      0      0    0          10,512,734   23.90%   
Shares                                                           
                                                                 
GB00B02TDY97                                                     

B: Financial Instruments                                                       
                                                                               
Resulting situation after the triggering transaction                           
                                                                               
Type of        Expiration     Exercise/       No. of voting      Percentage of 
financial      date           conversion      rights that may be voting rights 
instrument                    period/date     acquired (if the                 
                                              instrument                       
                                              exercised/                       
                                              converted)                       
                                                                               

Total (A+B)                                                                    
                                                                               
Number of voting rights                 Percentage of voting rights            
                                                                               
10,512,734                              23.90%                                 

9. Chain of controlled undertakings through which the voting rights and /or the
financial instruments are effectively held, if applicable:                     
                                                                               
The Royal Bank of Scotland Group plc (23.90%)                                  
                                                                               
The Royal Bank of Scotland plc (23.90%)                                        
                                                                               
Adam & Co Group plc (23.90%)                                                   
                                                                               
Adam & Co Investment Management Ltd (23.90%)                                   

Proxy Voting:                                                                  
                                                                               
10. Name of proxy holder:                                                      
                                                                               
11. Number of voting rights proxy                                              
holder will cease to hold:                                                     
                                                                               
12. Date on which proxy holder will                                            
cease to hold voting rights:                                                   

13. Additional information:             This notification is based upon the    
                                        Voting Rights figure of 43,990,545     
                                        obtained from your Regulatory          
                                        Announcement dated 27th January 2009.  
                                                                               
14 Contact name:                        Richard Hopkins                        
                                                                               
15. Contact telephone number:           020 7714 4459                          


For further information please contact:

Creon Corporation Plc Jonathan Freeman +44 (0)20 7752 0215

Daniel Stewart & Company Plc Oliver Rigby +44 (0)207 776 6550

GTH Media Relations Toby Hall +44 (0)20 7153 8039

Christian Pickel +44 (0)20 7153 8036


                                                                                                         

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