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Amvescap PLC (IVZ)

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Friday 01 November, 2002

Amvescap PLC

SAR - BRITISH BIOTECH PLC

Amvescap PLC
01 November 2002




                                                                      FORM SAR 3


Lodge with Company Announcements Office and the Panel.  A copy must also be sent
to the company the shares of which are acquired.

                                              Date of disclosure 1 NOVEMBER 2002

                             DISCLOSURE UNDER RULE 3 OF THE RULES GOVERNING
                               SUBSTANTIAL ACQUISITIONS OF SHARES ('SARs')

Date of acquisition 31 OCTOBER 2002

Acquisition in ........... BRITISH BIOTECH PLC ....... (name of company)

(1)     Class of voting shares          Number of shares/rights          If rights over shares
        (eg ordinary shares)            over shares acquired             acquired, as opposed
                                                                         to the shares
                                                                         themselves, specify
                                                                         nature of rights

        ORDINARY 5P                     19,000,000 shares                        -
             -                          N/A       rights                         -

(2)     Resultant total holding         Resultant total holding          Total percentage
        of voting shares (and %         of rights over shares
        of total voting shares          (and % of total voting
        in issue)                       shares in issue)

        161,468,526 (24.189%)                          -                 161,468,526 (24.189%)

(3)     Party making disclosure................ AMVESCAP PLC .................

(4)     (a)   Name of person acquiring shares or rights over shares  DISCRETIONARY
                                                       MANAGED CLIENTS OF AMVESCAP

              and, if different, beneficial owner ..............................

        (b)   Names of any other persons acting by                        
              agreement or understanding (see SAR 5)............................


Signed, for and on behalf of the party named in (3) above........A. TULLY......

(Also print name of signatory)............ANGELA TULLY.........................

Telephone and extension number............020 7454 3652........................



Note. Under SAR 5, the holdings of and acquisitions by persons acting by
agreement or understanding must be aggregated and treated as a holding of or
acquisition by one person.  Note 3 on SAR 5 requires persons who must aggregate
holdings to disclose certain disposals.


For full details of the SARs disclosure requirements, see Rules 3 and 5 of the
SARs.  If in doubt, contact the Panel on Takeovers and Mergers, Monitoring
Section.  Tel. No: 020 7638 0129.
Email:monitoring@disclosure.org.uk






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