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Antisoma PLC (SRC)

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Friday 19 April, 2002

Antisoma PLC

Director Shareholding

Antisoma PLC
19 April 2002

19 April 2002

                     Antisoma plc ('Antisoma' or the 'Company')

                            Directors' shareholdings

The Company has been notified today of changes to the interests of Directors in
the ordinary share capital of the Company following completion of the Rights
Issue, announced on 22 February 2002, and pursuant to the commitments made by
Directors to sub-underwrite up to 1,581,670 new Ordinary Shares.

The number of new Ordinary Shares subscribed for by each Director pursuant to
the sub-underwriting arrangements, at a price of 20p per share, is set out
against their name in the table below together with their resulting interest in
the issued ordinary share capital of the Company.

Name of Director                Number of new Ordinary    Resulting interest in   % of Issued Share
                                 Shares Subscribed for   issued Ordinary Shares        Capital

Glyn Edwards                                   603,794                  627,127         0.30
Raymond Spencer                                 67,569                  149,235         0.07
Barry Price                                    258,769                  492,102         0.24
Grahame Cook                                    89,133                  127,049         0.06
Michael Pappas                                 258,769                  272,769         0.13
James Coombes                                   86,256                   86,256         0.04



Antisoma plc                              020 8799 8200
Glyn Edwards
Raymond Spencer

                      This information is provided by RNS
            The company news service from the London Stock Exchange