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Xenova Group PLC (XEN)

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Wednesday 23 August, 2000

Xenova Group PLC

Holding in Company

Xenova Group PLC
23 August 2000


LETTER TO:  XENOVA PLC
Dated 16 August 2000

We act for Morgan Stanley Securities Limited (MSSL) and refer to a letter
(copy below) dated 22 June 2000 notifying you that they had effected
transactions (the Transactions) pursuant to which they had acquired an interest
in an aggregate of 2,251,000 ordinary 10p shares (the Shares) in Xenova PLC (the
Company) representing an aggregate of approximately 4.04% in the share capital
of the Company. The letter also referred to further transactions (the Further
Transactions) pursuant to which it had disposed of an interest in the Shares on
terms that Shares equivalent to them would be returned to MSSL at a future date
or dates.

We are informed by MSSL that as of today's date, the Transactions and the
Further Transactions have been closed out with the effect that MSSL has
ceased to have a notifiable interest in the Shares under section 198 of
the Companies Act.

LETTER FROM:  FRESHFIELDS BRUCKHAUS DERINGER


LETTER TO:  XENOVA PLC
Dated 22 June 2000

We hereby notify you that on 19 and 20 June 2000,  we effected transactions (the
'Transactions') pursuant to which Morgan Stanley Securities Limited ('MSSL')
acquired an interest in an aggregate of 2,251,000 ordinary 10p shares (the
'Shares') in Xenova PLC (the 'Company') representing an aggregate of
approximately 4.04% in the share capital of the Company.  The terms of the
Transactions contemplate that we will return Shares equivalent to those the
subject of the Transactions at a future date or dates.

At about the same time, we effected further transactions pursuant to which we
disposed of an interest in the Shares on terms that Shares equivalent to them
will be returned to us at a future date or dates.  As a result, our interest in
the Shares is an interest within the meaning of Section 208(5) of the Companies
Act 1985.

LETTER FROM: MORGAN STANLEY SECURITIES LIMITED