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Xenova Group PLC (XEN)

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Wednesday 10 May, 2000

Xenova Group PLC

Changes in Registered Holders

Xenova Group PLC
9 May 2000

Letter to Xenova Group plc

Companies Act 1985
Disclosures of Interest in Voting Shares - Changes in Registered Holders

In compliance with Part VI of the above Act, as amended, I inform you that, with
effect from Monday 8 May 2000, the registration details for some funds currently
managed by Prudential plc have changed.  As a direct result, the names of the
registered holders which comprise our notifiable interest in the voting shares
in your company will now be as listed on the report below.

It must be stressed that it is not a change to our notifiable interest in the
voting shares of your company that has generated this notification, but merely a
change in registration details.

                           Notifiables 
                         Position Report

Sedol:  0985000     Client Fund Reporting Group:  PPMB

Xenova Group    Shares in Issue   Registered Holder       Current    Holding
0985000                                                   Holding       %
Ord GBP 0.10       55,765,392     M&G (Lombard St) Noms   2,536,365    
                   55,765,392                             2,536,365    4.54

Letter from Colin Houghton
            for and on behalf of the Prudential plc
            020 7548 3801