Acquisition

Synexus Clinical Research PLC 24 October 2006 SNX.L Synexus Clinical Research PLC Acquisition of Clinical Research Centers SA (PTY) Ltd Synexus Clinical Research PLC ('Synexus' or 'Company'), the clinical trials services group, today announces that it has entered into a conditional agreement to acquire the entire issued share capital of Clinical Research Centers SA (PTY) Ltd ('CRC') for an initial consideration of £0.81m plus a maximum deferred consideration of £0.98m. The acquisition is conditional upon approval being received in respect of certain terms of the transaction from the South African Reserve Bank. This acquisition, the Company's third since joining AIM in November 2005, follows its stated strategy to build a multi-country operation, replicating its UK capability of recruiting large numbers of patients into later stage clinical trials for the pharmaceutical industry. Information on CRC CRC is a Site Management Organisation based in South Africa providing clinical trial services, particularly the recruitment and subsequent management of patients onto later stage clinical trials for the pharmaceutical industry. Benefits of the acquisition • CRC represents a further opportunity for the Company to exploit the growing clinical trials and patient recruitment markets in emerging economies. • The acquisition of CRC, a well-established business operating in the same area of activity as Synexus, complements the organic growth of the Company. • The acquisition of CRC is expected to be earnings accretive for Synexus for the year to 31 March 2007. • The acquisition both broadens the therapeutic offering of Synexus and provides access to a significant pool of previously untreated patients for clinical trials Details of the acquisition The maximum consideration of £1.80m is satisfied as follows: • £0.81m payable on completion (of which £0.25m is payable by way of the issue of 266,109 new ordinary shares in Synexus and the remainder in cash). • £0.25m deferred consideration payable in cash after completion of the Synexus year end audit. • Up to a further £0.74m payable in cash and shares, dependent on the level of profit after tax of CRC for the year ending 31 March 2008. In addition to its core later stage clinical trials business, CRC owns a 49% interest in AddClin Research (Pty) Ltd ("AddClin"), a joint venture with Adcock Ingram, the large South African multinational pharmaceutical business. Addclin carries out bioequivalence and pharmacokinetic studies for South African and international generics companies. Commenting on the acquisition, Michael Fort, Chief Executive of Synexus said: "We are delighted with the acquisition of CRC which not only extends our therapeutic range but also gives us a footprint in the Southern Hemisphere where we will be able to conduct contra-seasonal studies to those in the Northern Hemisphere into conditions such as hay fever and asthma, thereby extending our offering in these areas. "The interest in the joint venture in Phase I studies with Adcock Ingram is also exciting as this is not only a link with a large multinational healthcare company but is also a low risk entry into the early stage market. "We are especially pleased to welcome CRC's founder and managing director, Dr Sanet Aspinall to the operations board of Synexus Clinical Research plc. Her experience at the highest level within the medical community in South Africa will be of considerable value to Synexus." Note An exchange rate of £1 : 13.95 Za Rand has been used in this announcement in relation to the financial information on CRC. All payments of cash are to be made in Za Rand. Press enquiries Synexus Clinical Research plc Tel: +44 (0)1257 230723 Michael Redmond, Chairman Michael Fort, Chief Executive Biddicks - Financial Public Relations Tel: +44 (0)20 7448 1000 Zoe Biddick Brewin Dolphin Securities Tel: +44 (0)845 270 8600 Mark Brady/Sarah Kent This information is provided by RNS The company news service from the London Stock Exchange

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