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Sopheon PLC 10 October 2007 Embargoed Release: 07:00hrs Wednesday 10 October 2007 Sopheon Plc ('Sopheon') Leading European Center for Clinical Trials Research Selects Sopheon's Accolade(R) System The University Medical Center Utrecht Enhances Processes and Strengthens Position in Rapidly Expanding Trials Outsourcing Market Sopheon, the international software and services company, announced today that the University Medical Center (UMC) Utrecht, represented by its division the Julius Center, has selected Sopheon's Accolade product life cycle management system to support its processes for conducting trials. Julius' research program is comprised of initiatives sponsored by leading pharmaceutical companies, universities and the government, including clinical investigations that involve other UMC divisions. Pharmaceutical companies are expected to increase spending for outsourced R&D services by almost 15% annually for the next five years. The core of this trend is the outsourcing of clinical development, which more and more pharmaceutical executives see as a way to reduce costs and increase efficiency. The outsourced model also makes it possible to complete trials more quickly. The global growth in demand for outsourced clinical trial services is fueling new levels of business opportunity for independent research operations such as the Julius Center. Julius is a particularly attractive alternative because it has unique competencies in the management of complex, global clinical trials involving multiple medical centers. More than 2,000 clinical trials are completed across UMC Utrecht each year, and Julius conducts or oversees a large portion of these investigations. The adoption of Accolade will help the organization handle a steadily growing volume of trial activity. Accolade provides an automated process structure that will enable the Center's research and program management staff to accelerate trial preparation and execution. The system's data protection and management capabilities will contribute to ensuring trial security and quality, and facilitate more efficient collaboration among researchers. Implementation of the system will also support compliance with European GCP (Good Clinical Practice) directives for clinical trial execution. 'As acceptance of the outsourced model for clinical trials management has increased among public and private organizations, our project pipeline has become deeper and more complicated,' said Robert Veen, data management manager for the Julius Center. 'Our deployment of Accolade has allowed us to take project data previously recorded and stored on isolated tools like spreadsheets, and consolidate them in a single, easily accessed repository. The flexibility of the Accolade system, reflected in the fact that we can configure it on our own, provides us with a platform that can accommodate multiple processes and a nearly limitless range of specific process requirements. Accolade gives us confidence that our trials will be executed consistently and with the kind of rigorous quality control that will ensure the accuracy and reliability of their outcomes. Sopheon's solution will allow us to take the professionalization of our research processes to a whole new level.' 'The University Medical Center Utrecht is an international symbol of excellence in scientific research and education,' said Huub Rutten, Sopheon's vice president of research and development. 'Their clinical trial operations are, like Sopheon and Accolade, focused on helping organizations get better products to market faster. They have built their success on quality performance and an abiding commitment to the pursuit of best practices. We are proud to be able to contribute even indirectly to the invention of the important new medicines and treatments that result from their efforts.' - Ends - Accolade(R) is a registered trademark of Sopheon plc. All other trademarks and registered trademarks are the sole property of their respective owners. About Julius Center Founded in 1996, the Julius Center for Health Sciences and Primary Care is part of the University Medical Center Utrecht. It carries out scientific research, provides education, and offers expertise and facilities in the area of clinical health sciences, specializing in epidemiology, public health, general practice, nursing, dietary science, and medical technology assessment. The center has a leading and acquisitive position in the enlargement and dissemination of knowledge, especially in the field of health sciences. This is done by means of groundbreaking research and by the provision of courses for researchers and clinicians. For more information, please visit the research section at www.umcutrecht.nl About Sopheon Sopheon (LSE:SPE) is an international provider of software and services that help organizations improve the business impact of product innovation. Sopheon's Accolade system automates and governs the innovation process, enabling companies to increase revenue and profits from new products. Sopheon is listed on the AIM Market of the London Stock Exchange and on the Euronext in the Netherlands. For more information, please visit www.sopheon.com For further information contact: Barry Mence, Chairman Sopheon plc Tel : + 44 (0) 1483 685 735 Arif Karimjee, CFO Andrew Tan Hansard Tel : + 44 (0) 207 245 1100 + 44 (0) 7957 203 685 Floor van Maaren Citigate First Financial Tel : + 31 (0) 205 754 010 This information is provided by RNS The company news service from the London Stock Exchange

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