Preliminary Results

Hygea VCT plc 24 April 2007 Preliminary Results for the year ended 31 December 2006 Financial summary for the year ended 31 December 2006 31 December 2006 31 December 2005 Net assets £4,294,000 £5,679,000 Net revenue before tax £(167,000) £(324,000) Revenue loss per share* (2.2)p (4.3)p Net asset value per share 56.8p 74.8p * based on 7,555,017 (2005: 7,596,393) weighted average shares in issue in the year. Chairman's statement I am pleased to present the 2006 annual report to shareholders in Hygea VCT plc. At 31 December 2006 the Fund had a portfolio of 21 investments with 92.5% of net assets being represented by VCT qualifying holdings. In 2006 we have seen a mixture of results from our investee companies but, as is usually the case with venture capital funds, the poor results have impacted the overall value of the Fund's holdings before the Fund experiences the significant uplifts that can come from successful investments. In addition, since a substantial number of the investments have been held for less than three years, patience will be needed before the anticipated gains can be realised. Whilst we will take advantage of future investment opportunities as the availability of cash within the Fund allows, our main strategy will be, over time, to reduce the number of holdings in the portfolio and use the cash realised from disposals (mainly of the AIM portfolio) to support the key investments in the unquoted portfolio through to a listing or a trade sale. As a consequence of this, the Board, in conjunction with Octopus, is considering significant changes to the way the fund is managed and I expect to be writing to you with proposals in time for them to be put to shareholders at an EGM that will be held immediately following the AGM on 12 July 2007. We anticipate that these changes will lead to a further significant reduction in the Fund's overall running costs, while allowing us to gain further access to those skills that we believe will be important in allowing us to generate significant value from the portfolio of investments. Investment Policy During 2006, we made a further 3 investments in qualifying companies, taking us to the point where we finished the year with a portfolio of investments in 21 companies, of which 11 are quoted on AIM and 10 are unquoted. The Board is taking an active role in managing the portfolio. This involves providing investee companies with advice and contacts, as well as working with them to ensure that they achieve the progress that will be required in order for Hygea to generate value from its investments. Investment Environment During 2006 and early 2007, there have been a number of acquisitions of UK-based biotechnology companies. This activity has been driven by the need for many pharmaceutical companies to acquire additional compounds to add to their own pipelines of new products. I believe that this points to an environment in which the financial markets are likely to become more aware of the potential upside from investing in smaller UK healthcare and biotechnology companies. NAV The Net Asset Value per share ("NAV") as at 31 December 2006 was 56.8p, a decline of 18p compared with the equivalent figure at the end of 2005. Despite the decline in the reported value of the portfolio, many of the portfolio companies made good progress in 2006. In accordance with the valuation guidelines for holdings in unquoted companies, we were able to increase the carrying value of our holdings in three unquoted companies (Scancell Ltd, Insense Ltd and Prosurgics Ltd). However, we reduced the carrying value of our holdings in two unquoted companies (Hallmarq Veterinary Imaging Ltd and Purely Proteins Ltd) where progress has not been in line with our original expectations. Many of our unquoted holdings are still held at cost as, despite good progress in developing their businesses, they have not yet reached a point where the valuation guidelines permit us to write up the value of our holding. Our holdings in companies quoted on AIM experienced mixed fortunes during 2006. We saw strong share price performance from several of the holdings, but also suffered from the poor performance of a couple of others particularly Evolutec Group plc, where the share price fell 80% following the announcement of the failure of the company's lead product in a clinical trial. The NAV at the end of 2006 was also negatively impacted by the requirement for us to value our AIM-quoted holdings using the bid price, rather than the mid price. Although for most of our holdings this only results in a fairly minor negative impact on the valuation, for holdings where the shares tend to trade on a large spread between the buying and selling prices, the impact can be significant. More details on our current portfolio are set out in the Investment Manager's Review, which follows. As a result of the investments that were made during 2006, the Fund only had £94,000 of cash and money market securities at the end of 2006. Therefore, the income that is generated for the Fund from the cash and money market holdings will remain low for the foreseeable future. In addition, due to the nature of the underlying investments, the income that is generated from the portfolio is expected to be small, as few of the holdings pay dividends at present. Share Price The Board is aware that investors in VCTs sometimes need to sell their shares. As "second hand" VCT shares do not qualify for upfront income tax relief, there tends to be few purchasers of these shares. As a result of this imbalance, the share price has drifted to a point where at present it is some way below the underlying NAV. Given the small size of the Fund and its limited cash resources, the Board believes that it is preferable to focus on generating real value from the portfolio of investee companies to stimulate interest in the shares, rather than using the Fund's limited cash resources to carry out share buybacks. The Board, in common with many other VCTs, is exploring ways through which the benefits of investing in "second hand" VCT shares can be communicated. Meanwhile we have redeveloped our website and shareholders are encouraged to visit the site at www.hygeavct.com to follow progress of the portfolio. Board Towards the end of 2006, Mark Andrews resigned from the Board. I would like to take this opportunity to thank Mark for his contribution during his time on the Board. In view of the Board's discussions about the future strategy for the Fund, we do not believe that it is necessary to appoint a further director at present. VCT Qualifying Status PricewaterhouseCoopers LLP continues to provide the Board with advice on the ongoing compliance with HM Revenue & Customs rules and regulations concerning VCTs. The Board has been advised that Hygea VCT is in compliance with the conditions laid down by HM Revenue & Customs. Outlook During 2006, we completed the process of investing in a portfolio of investments in both AIM-quoted and unquoted companies. We also made substantial progress in reducing the Fund's cost base. We now have a strong base from which to build shareholder value going forwards. As previously indicated, I expect to be writing to all shareholders shortly with further proposals for the Fund's future development and management. I also look forward to meeting as many shareholders as possible at our AGM on 12 July 2007. James Otter Chairman 23 April 2007 Investment Manager's Review The Fund made a number of investments during 2006 and ended the year with a portfolio of investments in a total of 21 companies, 11 of which were quoted on AIM and 10 were unquoted. As at 31 December 2006, the portfolio was 43.5% invested in companies quoted on AIM, 54.3% in unquoted companies, and 2.2% in money market securities and cash. Review of portfolio During 2006, the Fund made 2 new investments in unquoted companies and increased its holdings in 4 other unquoted companies. In addition, 1 new investment was made into a business that is quoted on AIM. The new investments are as follows: * Prosurgics Ltd is a developer of robots for use in a range of surgical procedures. * Wound Solutions Ltd has developed a product that has potential applications in the treatment of leg ulcers. * Plethora Solutions Holdings plc is working on products that have applications in the treatment and management of certain urological disease conditions. In the closing months of 2006, movements in the share prices of two of the portfolio's AIM-quoted holdings illustrated the high risk/high return characteristics of investing in healthcare companies that are focused on drug development. In December 2006, we bought further shares in ReNeuron Group plc at a price of 10p per share by exercising warrants that the Fund owned. Later in the month, ReNeuron experienced a surge in its share price to more than 40p following the announcement of the filing of its application with the US regulators to commence clinical trials in stroke patients with its lead stem cell product. We took advantage of the period of volatility in the share price to sell a proportion of the Fund's holding, generating a profit of £63,000. Disappointingly, the value of the Fund's holding in Evolutec Group plc fell sharply following the publication of results from a clinical trial for its lead product, illustrating the abrupt change in valuation of a biotechnology company that can occur on the publication of trial results. Despite good data from previous trials, in the latest trial in patients suffering from hay fever, no significant benefits were found from using the drug. In August 2006, following a period of strong share price performance, we took the opportunity to dispose of the holding in Abcam plc at a share price that was approximately 60% higher than the price at which we had invested. In the unquoted portfolio, we have been pleased with the general progress that has been made by most of the holdings. We have increased the carrying value of three holdings where it has been possible to do so under the rules which govern the way in which we are permitted to value the holdings in unquoted companies. However, we have also made significant reductions in the carrying values of two unquoted companies to reflect the underlying performance of those businesses during 2006. Progress in 2007 Since the end of 2006, we have made several further adjustments to the portfolio. The Fund has invested a further £100,000 in Prosurgics Ltd, as part of a larger funding round. We have also sold the remaining shares in ReNeuron Group plc, realising a further profit of £83,000. In addition, we have disposed of the entire holding in DawMed Systems plc and Cobra Bio-manufacturing plc. In early April, we invested approximately £60,000 in Epistem Holdings plc, an AIM quoted biotechnology company that is commercialising adult stem cells in the areas of oncology and gastrointestinal diseases. Epistem also has a contract research division that has provided services to over 65 clients. Our ongoing challenge is to work closely with the investee companies in order to maximise the returns that are generated for the shareholders in the Fund. We anticipate that we may reduce the size of certain of our holdings in order to focus the portfolio into those holdings from which we expect to generate the greatest returns for shareholders. Ten largest holdings Scancell Ltd Scancell is a Nottingham-based biotechnology company that is developing a pipeline of drugs to target various types of cancer. These products are derived from Scancell's proprietary ImmunoBody technology. During 2006, the company sold its pipeline of antibodies to Peptech Ltd, an Australian biotechnology company, in a deal that had a total value of up to £4.85m. Initial investment December 2003 Cost £000's 725 Valuation as at 31.12.06 £000's 725 Basis of valuation Cost Equity held 12.6% Website www.scancell.co.uk Audited Financial Information Period ending 30 April 2006 £000's Sales 27 Loss before tax (716) Retained losses (734) Net assets 446 Wound Solutions Ltd Wound Solutions is working on the development of a product that has applications in the treatment of difficult to heal wounds such as leg ulcers and foot ulcers. There is a lack of effective treatment for patients with severe ulcers, and the market size is estimated to be 2.5 million patients in the US and Europe. Initial investment May 2006 Cost £000's 350 Valuation as at 31.12.06 £000's 350 Basis of valuation Cost Equity held 3.1% Website www.woundsolutions.com Audited Financial Information Period ending 30 June 2006 £000's Sales 0 Loss before tax (926) Retained losses (926) Net assets 3,330 DxS Ltd DxS is a leading provider of genetic analysis services to pharmaceutical companies and contract research organisations. The company's services include the provision of genetic testing using single nucleotide polymorphism technology and DNA extraction and banking. DxS's services are of particular use to pharmaceutical companies when they are conducting clinical trials as the genomic tests can be used to help identify groups of patients that are most likely to benefit from a particular therapy. David Evans, who is chairman of a number of AIM-quoted companies (including BBI Holdings plc and Epistem Holdings plc, both Hygea investee companies) became chairman of DxS in 2006. Initial investment April 2004 Cost £000's 326 Valuation as at 31.12.06 £000's 326 Basis of valuation Cost Equity held 8.3% Website www.dxsgenotyping.com Audited Financial Information Period ending 30 June 2006 £000's Sales 1,164 Loss before tax (502) Retained losses (456) Net assets (2,934) ImmunoBiology Ltd ImmunoBiology is a biotechnology company that is focused on developing products that could have applications in the treatment of cancer and certain infectious diseases. The company's technology is based on a recent discovery that a group of proteins known as "heat shock proteins" has a pivotal role in controlling the normal immune response to infections. Initial investment November 2005 Cost £000's 300 Valuation as at 31.12.06 £000's 300 Basis of valuation Cost Equity held 5.78% Website www.immbio.com Audited Financial Information Period ending 31 May 2006 £000's Sales 28 Loss before tax (495) Retained losses (495) Net assets (163) NeutraHealth plc NeutraHealth is an AIM-listed company that was established to acquire businesses operating in the neutraceutical sector. The company acquired Biocare Ltd, an established business in the neutraceutical sector, in August 2005. In January 2007, NeutraHealth announced the acquisition of Brunel Healthcare Ltd, for an initial purchase price of £4m, with a further £1.9m payable depending on the performance of Brunel over the next two years. Brunel, which distributes private label and branded vitamins and supplements through a number of outlets, including Tesco, Holland & Barrett, Superdrug and Waitrose, had turnover of £14m in 2006. Initial investment August 2005 Cost £000's 360 Valuation as at 31.12.06 £000's 295 Basis of valuation Bid price Equity held 2.43% Website www.neutrahealthplc.com Audited Financial Information Period ending 31 December 2006 £000's Sales 8,571 Profit before tax 902 Retained losses 590 Net assets 19,492 Hallmarq Veterinary Imaging Ltd Hallmarq is a Guildford-based company which specialises in developing low cost magnetic resonance imaging systems. The first application is for equine vets to enable the diagnosis of causes of lameness in horses that are not identifiable by any other method. Hallmarq has installed more than 30 units at leading equine veterinary practices and research centres around the world, and over 7,000 scans have been carried out on horses using equipment supplied by Hallmarq. James Otter, the Chairman of Hygea, is playing an active role at Hallmarq illustrating the way in which Hygea is able to work in a proactive manner with its investee companies in order to ensure that they fulfil their potential. Initial investment August 2005 Cost £000's 735 Valuation as at 31.12.06 £000's 288 Basis of valuation Latest funding round Equity held 7.3% Website www.hallmarq.net Audited Financial Information Period ending 31 August 2006 £000's Sales 1,438 Loss before tax (328) Retained losses (278) Net assets 1,199 BioAnaLab Limited BioAnaLab is a leader in the provision of specialist analytical services to pharmaceutical and biotechnology companies involved in the growing sector of biopharmaceuticals. More than 30% of all pharmaceutical products in development are made from proteins, which present particular analytical challenges in measuring drug levels, patient responses, and product efficacy in order to provide product validation and satisfy the requirements of the regulatory authorities. The company has experienced a substantial growth in revenue since Hygea invested in the business. A key development during 2006 was the appointment as chairman of David Oxlade, who has substantial experience leading companies in the pharmaceutical and biotechnology sector. Initial investment May 2005 Cost £000's 279 Valuation as at 31.12.06 £000's 279 Basis of valuation Cost Equity held 13.9% Website www.bioanalab.com Audited Financial Information Period ending 31 October 2006 £000's Sales 1,161 Profit before tax 98 Retained profit 98 Net assets 751 Prosurgics Ltd Prosurgics Ltd (formerly known as Armstrong Healthcare Ltd) is a leading image-guided surgical robotics company. The company's PathFinder robot enables surgeons to achieve a high level of accuracy in neurosurgery, enabling improved patient outcomes at lower cost. The EndoAssist is a robotic manipulator for the endoscope used in chest and abdominal surgery. It has a unique control system that is guided by head movement, giving the surgeon total control at a glance. Initial investment January 2006 Cost £000's 250 Valuation as at 31.12.06 £000's 275 Basis of valuation Latest funding round Equity held 7.05% Website www.prosurgics.com Audited Financial Information Period ending 31 December 2005 £000's Sales 300 Loss before tax (1,225) Retained losses (1,133) Net assets 213 Insense Ltd Insense is working on the development of an innovative product range for the wound care market. Its first product has completed clinical trials and the second product is currently undergoing clinical evaluation. Both products are expected to be approved by the relevant regulatory authorities in 2007 and to be launched onto the market shortly after approval is received. Initial investment July 2003 Cost £000's 167 Valuation as at 31.12.06 £000's 226 Basis of valuation Latest funding round Equity held 3.12% Website www.insense.co.uk Audited Financial Information Period ending 31 December 2005 £000's Sales 0 Loss before tax (893) Retained losses (893) Net assets 685 ReNeuron Group plc ReNeuron is a leading company in the field of cell therapies derived from stem cells. The company announced in December 2006 that it had filed an application with the US Food & Drug Administration to commence initial clinical trials in the US for its lead product, a stem cell therapy for treating stroke patients. As a result of the strong share price performance, the Fund's remaining stake was sold in early 2007. Initial investment August 2005 Cost £000's 82 Valuation as at 31.12.06 £000's 195 Basis of valuation Bid price Equity held 0.42% Website www.reneuron.com Audited Financial Information Period ending 31 March 2006 £000's Sales 9 Loss before tax (6,826) Retained losses (6,313) Net assets 4,628 Summary of investments made by other funds managed by Octopus Investments Ltd It is a requirement that Octopus discloses if some of its other funds are also invested in any of the Hygea VCT portfolio companies. Details of these are shown below. % equity held by % equity held by Company name Hygea VCT other funds BBI Holdings plc 0.30% 3.30% DawMed Systems plc 2.20% 1.71% NeutraHealth plc 2.43% 1.37% Plethora Solutions Holdings plc 0.14% 0.36% Prosurgics Ltd 7.05% 0.68% The above data is as at 31 December 2006. Octopus Investments Ltd 23 April 2007 Income Statement Year ended 31 December Year ended 31 December 2006 2005 Revenue Capital Total Revenue Capital Total £000's £000's £000's £000's £000's £000's Realised gain on investments - 82 82 - 8 8 Unrealised loss - (1,199) (1,199) - (123) (123) on investments Income Investment 21 - 21 34 - 34 management fees (21) (61) (82) (59) (177) (236) Other expenses (167) - (167) (299) - (299) Loss on ordinary activities (167) (1,178) (1,345) (324) (292) (616) before tax Tax on ordinary activities - - - - - - Loss on ordinary activities after (167) (1,178) (1,345) (324) (292) (616) tax Loss per share (2.2)p (15.6)p (17.8)p (4.3)p (3.8)p (8.1)p - The 'Total' column of this statement is the profit and loss account of the company. - All revenue and capital items in the above statement derive from continuing operations. Reconciliation of movements in shareholders' funds Year ended Year ended 31 December 2006 31 December 2005 £000's £000's Shareholders' funds at start of 5,679 6,299 year Middle market price to bid price - (4) valuation movement Restated shareholders' funds at 5,679 6,295 start of year Loss on ordinary activities after (1,345) (616) tax Cost of share buyback (40) - Shareholders' funds at end of year 4,294 5,679 Balance Sheet 31 December 31 December 2006 2005 £000's £000's Fixed asset investments 4,156 4,428 Current assets Debtors 77 13 Cash at bank 94 1,369 171 1,382 Creditors: amounts falling due within one year (33) (131) Net current assets 138 1,251 Net assets 4,294 5,679 Called up equity share capital 3,765 3,798 Share premium 1,722 1,722 Special distributable reserve 1,660 1,700 Capital redemption reserve 38 5 Capital reserve - realised (513) (534) - unrealised (1,879) (680) Revenue reserve (499) (332) Total equity shareholders' funds 4,294 5,679 Net asset value per share 56.8p 74.8p Year ended Year ended Cash Flow Statement 31 December 2006 31 December 2005 £000's £000's £000's £000's Net cash outflow from operating activities (390) (213) Financial investment : Purchase of investments (1,068) (3,183) Sale of investments 223 23 Net cash outflow from financial investment (845) (3,160) Net cash outflow before financing (1,235) (3,373) Financing : Repurchase of own shares (40) - Total financing (40) - Decrease in cash resources (1,275) (3,373) Notes to the preliminary announcement Fixed asset investments Unquoted AIM-quoted Total investments investments Book cost as at 1 January 2006 2,657 2,451 5,108 Unrealised depreciation at 1 January 2006 (242) (438) (680) Valuation at 1 January 2006 2,415 2,013 4,428 Movements in the year: Purchases at cost 945 123 1,068 Disposals - (223) (223) Net realised gain - 82 82 Increase in unrealised losses (398) (801) (1,199) Valuation at 31 December 2006 2,962 1,194 4,156 Comprising: Book cost at 31 December 2006 3,602 2,433 6,035 Unrealised appreciation at 31 December 2006 (640) (1,239) (1,879) All AIM-quoted investments are in ordinary shares with full voting rights. Unquoted investments are in ordinary shares with full voting rights with the exception of DxS Ltd and Hallmarq Veterinary Imaging Ltd where a proportion of the investment is held in loan stock. Details of the investments are shown below: 31 December 2006 Cost Valuation £000's £000's Unquoted investments BioAnaLab Ltd 279 279 DxS Ltd 30 30 Loan stock 296 296 Glide Pharmaceutical Technologies Ltd 100 100 Hallmarq Veterinary Imaging Ltd 600 153 Loan stock 135 135 ImmunoBiology Ltd 300 300 Insense Ltd 167 226 Prosurgics Ltd 250 275 Purely Proteins Ltd 370 93 Scancell Ltd 725 725 Wound Solutions Ltd 350 350 3,602 2,962 AIM-quoted investments Angel Biotechnology Holdings plc 750 79 BBI Holdings plc 74 120 Cobra Bio-manufacturing plc 125 62 DawMed Systems plc 101 34 Evolutec Group plc 347 43 NeutraHealth plc 360 274 Phoqus Group plc 150 110 Plethora Solutions Holdings plc 83 69 ReNeuron Group plc 93 195 Stem Cell Sciences plc 250 113 York Pharma plc 100 95 2,433 1,194 6,035 4,156 The above summary of results for the year ended 31 December 2006 does not constitute statutory financial statements within the meaning of section 240 of the Companies Act 1985 and has not been delivered to the Registrar of Companies. Statutory financial statements will be filed with the Registrar of Companies in due course; the auditors report on those financial statements under S235 of the Companies Act 1985 is unqualified and does not contain a statement under S237 (2) or (3) of the Companies Act 1985. A copy of the full annual report and financial statements for the year ended 31 December 2006 is expected to be posted to shareholders shortly and will be available to the public at the registered office of the company at 8 Angel Court, London, EC2R 7HP. ENDS ---END OF MESSAGE---
UK 100

Latest directors dealings