Proposed acquisition

Nutrinnovator Holdings PLC 26 May 2005 EMBARGOED FOR 07:00AM THURSDAY 26 MAY 2005 Nutrinnovator Holdings plc ('Nutrinnovator' or 'the Company') Proposed acquisition of Provexis Limited ('Provexis') Proposed Capital Reorganisation Proposed Placing of 67,424,000 new Ordinary Shares of 1p each at 5.6p per share Proposed conversion of £2,090,333.34 of Loan Proposed change of name to Provexis plc an Application for re-admission to trading on AIM * Nutrinnovator today announces it has reached agreement with Provexis' shareholders to acquire, subject to shareholders' approval, the whole of the issued share capital of Provexis for a consideration of 111,658,555 Ordinary Shares at the Placing Price of 5.6 pence per share (this reflects the proposed new capital reorganisation so that every 1 Ordinary Share of 2 pence will be sub-divided into 2 Ordinary Shares of 1 penny each), valuing Provexis at approximately £6.3m. The Company has received undertakings from shareholders holding approximately 76% of its current issued ordinary share capital that they will vote in favour of the acquisition and proposals relating to it at the forthcoming EGM to be held on 20 June 2005. * Provexis is a nutraceutical company, founded in 1999, which develops scientifically-proven, proprietary, functional foods, supplements and medical foods. Functional foods are foods which are consumed for the maintenance of health and have the potential to carry health claims to this effect. * Provexis' lead technology is CardioFlow which is a proprietary extract of tomato, produced industrially to laboratory-determined specifications. CardioFlow contains a range of tomato-derived components which inhibit platelet aggregation, a part of the blood-clotting process which can cause heart attack and stroke. * The first commercially available product containing CardioFlow will be a fruit juice drink called Sirco. The Company is in discussions with major high-street retailers and multiple grocers to secure distribution channels for Sirco and it aims to launch it in two major UK retailers in the final quarter of 2005. * It is intended to seek to develop revenues from licensing the CardioFlow technology to international brand owners. * In order to provide working capital for the Enlarged Group, in which existing Provexis shareholders will have a majority interest on Admission, the Company proposes to effect a Capital Reorganisation, a Placing to raise approximately £3.8m (before expenses) and a conversion of approximately £2.1m of loans. * On Completion, Dawson Buck will become Non-Executive Chairman and Dr Neville Bain, Non-Executive Deputy Chairman. Dr Stephen Franklin will become Chief Executive and Stephen Moon, Commercial Director. * Doug Gardner, Finance Director has stepped down from the Board. Fiona Vigar, Marketing Director has resigned from the Board but will remain with the Enlarged Group and Thornton Mustard, Non-Executive Director has resigned from the Board, but will continue as a consultant to the Enlarged Group. * Notice has been given of an EGM to approve the Proposals, including the change of name of the Company to Provexis plc, to be held at 10.00am on 20 June 2005. * Admission of the Ordinary Shares, including the New Ordinary Shares, is expected to take place on Thursday 23 June 2005, and dealings are expected to commence in the Enlarged Share Capital on AIM with effect from 8.00am on that date. Stephen Moon, Managing Director of Nutrinnovator, commented: 'We are excited to announce this deal. In addition to CardioFlow our combined technology pipeline is very promising. The Enlarged Group's business model, fuelled by a strong innovation pipeline, will develop a revenue stream based on both direct sales of Sirco and licensing revenues from our functional food technologies. We would also like to thank Doug Gardner for his contribution to the development of the Company and wish him every success in the future.' Dr Stephen Franklin, Chief Executive Officer of Provexis, added: 'We are delighted to announce the proposed reverse takeover of Nutrinnovator Holdings plc. The rationale for integrating the two businesses is compelling with the Enlarged Group combining a strong scientific team and impressive marketing and sales expertise. We believe that the Enlarged Group will be clearly differentiated in the functional food industry in that it will develop innovative functional food products with health benefits that are scientifically-proven and therefore have the potential to carry credible health claims and endorsements. When one combines this with proven speed-to-market credentials, we believe the result is a company well positioned in the rapidly growing functional food market'. The above summary should be read in conjunction with the full text of this announcement set out below. For further information please contact: Nutrinnovator Holdings plc Stephen Moon, Managing Director 020 8392 6637 Provexis Limited Dr Stephen Franklin, CEO 0151 795 4200 Oriel Securities Limited Andrew Edwards 020 7710 7600 Arbuthnot Securities Limited Tom Griffiths 020 7012 2000 Bell Pottinger Corporate and Financial Ann-Marie Wilkinson/Emma Kent 020 7861 3232 This announcement does not constitute an offer to sell, or the solicitation of an offer to buy, shares in any jurisdiction in which such offer or solicitation is unlawful and, in particular, is not for distribution into the United States, Canada, Australia, the Republic of Ireland or Japan. Neither the Existing Ordinary Shares nor the Ordinary Shares have been, nor will they be registered under the United States Securities Act of 1933, as amended, or under the applicable securities laws of any state of the United States, Canada, Australia, the Republic of Ireland or Japan. Accordingly, subject to certain exceptions, neither the Existing Ordinary Shares nor the Ordinary Shares may, directly or indirectly, be offered or sold within the United States, Canada, Australia, the Republic of Ireland or Japan or to or for the account or benefit of any national, resident or citizen of the United States, Canada, Australia, the Republic of Ireland or Japan. The distribution of the Prospectus in other jurisdictions may be restricted by law and therefore persons into whose possession the Prospectus comes should inform themselves about and observe any such restrictions. Any failure to comply with these restrictions may constitute a violation of the securities law of any such jurisdictions. Oriel Securities Limited, which is regulated by the Financial Services Authority, is acting as Nominated Adviser and Broker to Nutrinnovator up to Admission and for no-one else and will not be responsible to any person other than Nutrinnovator for providing the protections afforded to customers of Oriel Securities Limited nor for advising any other person on the contents of this announcement or any transaction or arrangement referred to herein. The responsibilities of Oriel Securities Limited as Nutrinnovator's Nominated Adviser and Broker under the AIM Rules are owed solely to the London Stock Exchange. Oriel Securities Limited is not making any representation or warranty, express or implied, as to the contents of this announcement (without limiting the statutory rights of any person to whom this announcement is issued). Arbuthnot Securities Limited, which is regulated by the Financial Services Authority, is acting as Nominated Adviser and Broker to the Company on Admission and no-one else and will not be responsible to any person other than the Company for providing the protections afforded to customers of Arbuthnot Securities Limited or for advising any other person on the contents of this announcement or any transaction or arrangement referred to herein. The responsibilities of Arbuthnot Securities Limited as the Company's Nominated Adviser and Broker on Admission under the AIM Rules are owed solely to the London Stock Exchange. Arbuthnot Securities Limited is not making any representation or warranty, express or implied, as to the contents of this announcement (without limiting the statutory rights of any person to whom this announcement is issued). Proposed acquisition of Provexis Limited Proposed Capital Reorganisation Proposed Placing of 67,424,000 new Ordinary Shares of 1p each at 5.6p per share, Proposed conversion of £2,090,333.34 of Loans Proposed change of name to Provexis plc and Application for re-admission to trading on AIM 1. Introduction Following the suspension of trading in the Existing Ordinary Shares on AIM on 18 February 2005, the Company announces today that it has entered into a conditional agreement with Provexis' shareholders to acquire the whole of the issued share capital of Provexis for a consideration of 111,658,555 Ordinary Shares. The Consideration Shares will be issued at 5.6 pence per share, valuing Provexis at approximately £6.3 million. Provexis is a nutraceutical company that develops scientifically-proven, proprietary, functional foods, supplements and medical foods. In order to raise additional working capital for the Enlarged Group, the Company has announced that it proposes to raise approximately £3.8 million before expenses pursuant to the Placing through the issue of 67,424,000 new Ordinary Shares at 5.6 pence per share. In addition, the Company is proposing to issue 37,327,381 new Ordinary Shares at 5.6 pence per share in satisfaction of the Loans. Following completion of the Proposals, the Vendors will hold 150,772,079 Ordinary Shares, which will represent approximately 60.4 per cent. of the Enlarged Share Capital. In view of its size, the Acquisition will constitute a reverse takeover of Nutrinnovator under the AIM Rules and therefore requires the approval of Shareholders at an Extraordinary General Meeting of the Company. Additionally, because the Concert Party will own more than 30 per cent. of the Enlarged Share Capital, the Company is seeking a waiver under Rule 9 of the City Code, which would otherwise require the Concert Party to offer to acquire those Ordinary Shares that it does not own. A resolution seeking the approval of Shareholders for such a Waiver is therefore included in the notice of Extraordinary General Meeting as set out in the Prospectus. The Acquisition, Placing and the conversion of the Loans are conditional, inter alia, upon the passing of the Resolutions to be proposed at the Extraordinary General Meeting, and upon Admission. 2. Background to and reasons for the Acquisition Nutrinnovator Limited was incorporated in May 2002, and its business was developed from February 2003 onwards. Early stage work involved working with nutritionists and product and process technologies to develop a food bar product (to compete in the cereal bar market) which was intended to be nutritionally superior to competing products, whilst offering a superior taste. Second stage work involved palatability development and research, using the services of Thornton Mustard, a taste and aroma specialist, and developing a brand and design strategy. Sourcing and negotiating a manufacturing agreement moved in parallel with this process. A product was ready for market launch in September 2003 and some limited distribution was achieved. At the beginning of 2004, a marketing strategy was put into action with the intention of building consumer awareness. Products are currently sold under the brand, Altu, in several nationally-recognised retail chains. The products also have a presence in the wholesale and independent retail channels. Nutrinnovator has obtained trade mark registration for the Altu brand name in the UK. In June 2004 Nutrinnovator was admitted to AIM and carried out a placing of 3,235,849 Existing Ordinary Shares at a price of 53p per share, raising approximately £1.7 million, before expenses, which has provided working capital for Nutrinnovator to continue to develop and market its products. On 22 September 2004, it was announced that Provexis had agreed a joint venture with Nutrinnovator to develop Sirco, a new 'heart-healthy' drink. The drink is a juice drink containing a patented natural fruit extract which has been proven in human trials to inhibit blood platelet aggregation and thereby benefit the circulation - working within a rapid timeframe i.e. up to three hours. It was initially anticipated that the joint venture would be 55 per cent. owned by Provexis and product development would be funded by Nutrinnovator's cash resources. The Directors believe that the acquisition of Provexis and Admission of the Enlarged Share Capital to trading on AIM will enhance the Company's activities. The two businesses are complementary and significant synergies can be achieved by merging the operations of the two companies. The Enlarged Group will have a pipeline of potential products and the Acquisition will allow the Enlarged Group to combine Provexis' technology with the Group's marketing and sales capability which the Directors and Proposed Directors believe will enhance the ability to develop and launch brands in a relatively short timeframe whilst continuing to implement a licensing strategy. The primary focus for the Enlarged Group will be the development of Sirco and the Board will conduct a review of the Altu brand following Admission. These products will address the functional food market, which has shown growth in the UK from £134 million of sales in 1998 to £835 million of sales in 2003. The market is forecast to grow to £1.7 billion of sales by 2007. By 2010, the US market for functional food is forecast to double from 2003 levels to $34 billion of sales. 3. Information on Provexis and its business Provexis was founded in 1999 by Progeny BioVentures Ltd, the life science subsidiary of ANGLE plc, a consultancy and venture creation company whose shares are traded on AIM. In January 2000, Progeny BioVentures Ltd, Rowett Research Services Ltd (the commercial arm of the Rowett Research Institute) and Provexis entered into an agreement for Provexis to source and develop patented bioactive products derived from food for application in the medical food and functional food markets. Functional foods are foods which are consumed for the maintenance of health and have the potential to carry health claims to this effect. Medical foods are a separately regulated category of products in the US and Europe, based on food but used under the supervision of a physician. From foundation until 2002, ANGLE provided Provexis with management, administrative support and funding. In September 2002, Dr. Stephen Franklin joined Provexis as Chief Executive and Provexis secured its first external venture capital (other than from ANGLE) from the Rising Stars Growth Fund (managed by Enterprise Ventures Limited) and management. From 2003, ANGLE has continued to provide administrative, accounting and financial support services to management. In October 2003, the company entered into a technology option agreement and a research and development collaboration with the University of Liverpool. In 2004, Provexis secured additional venture capital investment from ANGLE, the North West Equity Fund, the Rising Stars Growth Fund, Rowett Research Services Ltd and management. Provexis' approach is to prove the efficacy of its products in human trials. The Directors and Proposed Directors believe this approach supports the development of higher value products, with the potential for stronger patent positions, capable of being marketed with substantive health claims. Provexis has three products in development and an on-going 'right of first view' agreement with Rowett Research Services Ltd. The lead technology, CardioFlow, is a patented natural extract from tomato which has been shown in human trials to reduce the propensity for aberrant blood clotting, typically associated with CVD, which can lead to heart attack and stroke. The first patent application for CardioFlow was filed in the UK in 1998, followed by Europe, the USA, Japan, Canada, Mexico and Australia in 1999. The patent was granted in Europe in July 2003 and subsequently granted in Australia. The USA patent application successfully obtained its Notice of Allowance in March 2005 and the Directors and Proposed Directors anticipate that grants in Japan, Mexico and Canada will follow in due course over the next twenty-four months. The market for heart healthy foods worldwide was forecast to reach US$4.6 billion of sales by 2005. Whilst there are food products for the management of cholesterol, the Directors and the Proposed Directors are currently unaware of any food product in the UK *market that bears the on-label claim 'helps to maintain a healthy heart and benefits circulation' and the first product in development is a fruit juice based drink incorporating CardioFlow technology which will carry this on-label claim. Another product in development is a medical food product for the dietary management of Inflammatory Bowel Disease ('IBD'), specifically Crohn's Disease, using an extract of plantain. Provexis has entered into a collaboration agreement with the University of Liverpool to commercialise their technology in this field which is the subject of a patent application filed in 2004. A further product in planning is a pill variant of CardioFlow for application as: * a dietary supplement for 'healthy' people who wish to gain the cardiovascular benefit of the technology; and/or * a medicinal product for 'at risk' patients who are pro-thrombotic. 4. The Enlarged Group's product development CardioFlow In recent years, several studies have suggested a link between tomato consumption and the lower incidence of CVD in Mediterranean countries. Professor Asim Dutta-Roy of the Rowett Research Institute suggested that naturally occurring antiplatelet compounds in ripe tomato fruit could contribute to this effect. His discovery in 1998 formed the basis of a patent application prior to any subsequent third party validation. This intellectual property, which is now owned by Provexis, has been used in the development of a proprietary product called CardioFlow. CardioFlow is an extract of tomato, produced industrially to laboratory-determined specifications. It contains a range of tomato-derived components that inhibit platelet aggregation, a key part of the blood-clotting process. Blood platelets play an essential physiological role in detecting and initiating repair to damaged blood-vessel walls. However, it has also been established that this function can help turn an unstable or ruptured atherogenic plaque into a life-threatening arterial blockage, which can cause heart attacks and stroke. The active components in CardioFlow help to maintain platelets in an inactivated state, reducing the potential for platelet aggregation, which is desirable for good cardiovascular health. For patients with CVD, therapy with antiplatelet drugs has been shown to decrease the incidence of primary and secondary coronary events. However, for both patients and 'healthy' individuals, dietary control is being increasingly emphasised as crucial to heart health. The Directors and the Proposed Directors believe that opportunities for a natural, food-based product (positioned within the mainstream food market) with antiplatelet benefits are significant. The amount of tomatoes consumed in the normal UK diet is often too low to fully realise the cardiovascular benefits of the fruit. CardioFlow, however, provides an appropriate level of tomato extract in a form that can be added to a range of (specifically non-tomato-based) food products. CardioFlow is a functional food ingredient targeted at the 'heart healthy' food market. The Directors and Proposed Directors also believe that in the future it may prove to be an effective and natural replacement or augmentation for existing drug therapy, and are planning a pill or tablet format. To date, CardioFlow has been administered as a functional food to over 220 healthy human volunteers in four separate human trials. These trials have shown that: * the compounds responsible for CardioFlow's in vitro bioactivity are also efficacious in vivo. A rapid reduction in platelet responsiveness to important aggregation mediators, adenosine, diphosphate and collagen is observed when CardioFlow is taken orally, compared to control; * CardioFlow is well tolerated, with no reported adverse side affects. No effects on the coagulation process have been observed, suggesting that normal blood clotting on injury is not likely to be affected by CardioFlow supplementation. CardioFlow has been the subject of an independent professional risk assessment conducted by Toxicology Advisory Consultant Services, a strategic partner of the British Industrial Biological Research Association (BIBRA), which has deemed the ingredient safe. In addition, in 2003 CardioFlow gained regulatory clearance from the UK Food Standards Agency, which has deemed the ingredient to be non-novel (i.e. not subject to the EU Novel Foods Regulations); * CardioFlow shows efficacy in reducing the level of platelet aggregation in 'healthy' human subjects within three hours of ingestion; * the magnitude of the antiplatelet effect varies from person to person and male individuals show a significantly greater response to CardioFlow than females; * individuals may be classified as either low or high responders to the bioactive compounds in CardioFlow. Results suggest that the most responsive individuals, i.e. those showing the largest reductions in platelet aggregation response after consuming CardioFlow, may be those with significantly higher levels of some markers of increased CVD risk. In these individuals, the reduction in platelet aggregation observed can be greater than 70 per cent.; * as expected from its broad range of in vitro activities, CardioFlow exhibits more than one mode of action in vivo. The Directors and the Proposed Directors believe that, as a result, CardioFlow's bioactive components can alter platelet function in up to approximately 97 per cent. of individuals tested. This compares favourably with aspirin, which has one mode of action only, and is thought to be effective in approximately 70 per cent. of individuals; and * the benefits for CardioFlow continue for up to 18 hours after ingestion. Trials have indicated that the antiplatelet effect of CardioFlow is typically at a maximum between three and six hours after ingestion and that platelet function has returned to normal levels after approximately 18 hours. CardioFlow has also successfully completed stability tests under a range of conditions intended to accommodate several types of food vehicle. It has been formulated to minimise its colour, flavour and aroma and is therefore suitable for incorporation into a wide range of foods. The first commercially available product containing CardioFlow technology will be a fruit juice drink called Sirco. The beverage is planned to be on the shelves of two major UK retailers by the last quarter of this year. Sirco is proposed to be made available as a one litre carton and will be initially available in two flavours, blueberry & apple and orange. Both these flavour variants have been developed by Thornton Mustard, formerly a non-executive director of the Company, who has worked on global brands for a number of companies including Coca Cola, Proctor & Gamble, Red Bull, Diageo and GlaxoSmithKline. The drink will carry the claim that it 'helps to maintain a healthy heart and benefits circulation'. So far as the Directors and the Proposed Directors are aware, this is the first known beverage to carry this claim and so far as the Directors and Proposed Directors are aware, is the first to offer a heart-health benefit that works with your body on the very day you drink it. In addition to direct sales from the Sirco juice drink, the Directors and Proposed Directors believe that the possible licensing of the CardioFlow technology to international brand owners may provide an additional revenue stream. The Enlarged Group intends to license the technology under a proposed new brand, FruitFlow. Plantain extract for the dietary management of Crohn's Disease Ulcerative colitis and Crohn's disease are disorders of the digestive tract, known as inflammatory bowel disease (IBD). The inflammation is chronic, yet spontaneously relapsing. Evidence suggests that an abnormal reaction to endogenous intestinal bacteria may cause the condition. Provexis, in collaboration with the University of Liverpool, has demonstrated that a soluble fibre formulation (specifically, a non-starch polysaccharide extract) extracted from plantain reduces the attachment of bacteria to bowel epithelial cells in vitro. The idea that an extract from plantain could be linked to the management of IBD is given further credence by epidemiological evidence, which suggests that in continents where plantain is a staple ingredient (used to make flour, etc), the incidence of the condition is relatively low. Provexis is currently developing a novel, medical food for the treatment and management of IBD which is targeting maintenance of remission for patients with Crohn's Disease. The medical food product is currently expected to go into a human trial by the end of 2005. Current treatment of IBD generally involves the use of antidiarrhoeal agents, antispasmodic agents, aminosalicylates, corticosteroids, immunosuppressants and antibiotics. In the UK such treatments are prescription-only medicines, relatively expensive, aggressive and can have side effects. Near-term pipeline opportunities The Company is currently negotiating heads of agreement in relation to a licence of a functional food technology developed by a UK based institute which it is hoped will lead to a three-year research and development programme for a novel product which is expected to show risk reduction in a number of cancers. These discussions may or may not lead to legally binding agreements. The Company has a three year agreement with Plant Biosciences Limited ('PBL'), the technology transfer business of the John Innes Centre. PBL will access their global network of 35 academic and research institutes to seek further functional food technologies for the Company. 5. Manufacturing The Enlarged Group intends to outsource the manufacture of the CardioFlow ingredient to a plant facility at Fermoy, in County Cork, Ireland. The Enlarged Group will retain control of the raw-material supply chain (to ensure appropriate quality) and quality control procedures. The capacity planning suggests that if sales targets are achieved, this facility will be able to meet the Company's requirements for at least the first 24 months. Gerber Foods Limited ('GFL'), the UK's largest manufacturer of juice and juice drinks, manufactured the pilot samples for Sirco and the Company is in negotiations with GFL to manufacture Sirco in the UK. Subject to a satisfactory conclusion of negotiations with GFL this arrangement will allow the Enlarged Group to benefit from significant scale in fruit-juice purchasing and manufacturing costs which the Directors and the Proposed Directors believe will enhance gross margins. 6. Intellectual Property CardioFlow The first patent application for the CardioFlow antiplatelet product was filed in the UK in 1998, followed by subsequent patent applications in Europe, the USA, Japan, Canada, Mexico and Australia in 1999. The patent was granted in Europe in July 2003 and subsequently granted in Australia. The USA patent application successfully obtained its Notice of Allowance in March 2005 and the Directors and Proposed Directors anticipate that grants in Japan, Mexico and Canada will follow in due course over the next twenty-four months. In addition to the core parent patent, an additional patent application has been filed in Europe to protect aspects of CardioFlow's formulation, particularly with regard to dry powders and pills, which will have particular relevance for the development of the medical food product. Similarly, a new and more recent application has been made with regard to CardioFlow's newly discovered potential therapeutic use. Plantain extract for the dietary management of Crohn's Disease The plantain extract technology is also protected by patent application and is currently owned by the University of Liverpool. Provexis has an option to acquire rights to the patent application and other intellectual property rights relating to technology for the treatment of inflammatory bowel disease. These rights will be held in a subsidiary held 75 per cent. by Provexis and 25 per cent. by the University of Liverpool. The patent application has been the subject of an international search report and an international preliminary report on patentability, both of which are encouraging with regard to the likelihood of the patent being granted. 7. Sales and Marketing Sirco The Enlarged Group's proposed investment in marketing in respect of the Sirco brand will have two major platforms: national press and outdoor advertising, to raise awareness of the brand and its novel claims; and medical marketing, to influence directly opinion leaders and medical professionals. At the retailer level, the Enlarged Group intends to invest in activities such as point-of-sale shopper education, loyalty-card promotion and in-store sampling. The Company is in discussions with a number of major high-street retailers and multiple grocers for the sales of Sirco and the aim is to launch in two major UK retailers in the final quarter of 2005. Planned overall investment levels are designed to ensure that the Sirco brand will be focussed on the consumer and the trade customer, with approximately £2.2 million planned to be invested in marketing in the UK over the first two years. This compares with the total advertising investment in the UK by Tropicana of approximately £1.4 million in 2003 and the estimated £0.9 million invested in UK advertising by Ocean Spray in 2003. The Enlarged Group plans to build its own sales operation, comprising two people with healthcare sales experience to work with key retail customers to educate the consumer at store level and establish the Sirco brand. Altu food bar Altu was launched in 2003 and the brand is distributed nationally. Sainsburys, Waitrose, Boots, Holland & Barrett, GNC and Julian Graves form the core of Altu's multiple-grocer and high-street outlets, while the recent addition of Palmer & Harvey's delivered wholesale business has given the brand access to the convenience store sector. The product continues to receive support from existing customers and consumers. The Company intends to support current distribution via in-store promotions and sampling. A new multipack format was launched in Waitrose during March 2005. The primary focus for the Enlarged Group will be the development of Sirco and the Board will conduct a review of the Altu brand following Admission. 8. Financial information on the Group The Group had net assets as at 31 December 2004 of £0.6 million. A summary of the trading results for the Group, as extracted from the accountants' report set out in Part III of the Prospectus, is set out below. Period ended Period ended Period ended 31 May 31 March 31 December 2003 2004 2004 £'000 £'000 £'000 Turnover - 75 231 Gross Profit - 23 76 Operating Loss (81) (860) (1,744) Loss before taxation (81) (856) (1,729) 9. Financial information on Provexis Provexis had net assets as at 31 December 2004 of £0.1 million. A summary of the trading results for Provexis, as extracted from the accountants' report set out in Part IV of the Prospectus, is set out below. 8 month Period ended Year Ended 30 April 31 December 2002 2003 2004 2004 £'000 £'000 £'000 £'000 Turnover 1 - - - Other Operating income - - 22 23 Operating Loss (129) (387) (569) (327) Loss before taxation (129) (386) (566) (394) 10. Current trading and prospects of the Enlarged Group Nutrinnovator's current trading has been slower than originally expected, however the Altu product continues to receive support from existing customers and consumers. A new multipack format was launched in Waitrose in March 2005. Provexis has yet to make any sales but the Company is in discussions with a number of major high-street retailers and multiple grocers for the sales of Sirco and the aim is to launch in two major UK retailers in the final quarter of 2005. The two businesses are complementary and the Directors and Proposed Directors believe that significant synergies can be achieved by merging the operations of the two companies. Both companies have a pipeline of potential products and the Directors and Proposed Directors believe that the acquisition of Provexis and Admission of the Ordinary Shares to trading on AIM will enhance the Group's activities and profile. The Acquisition will allow the Enlarged Group to combine Provexis' technology with the Group's marketing and sales capability which the Directors and the Proposed Directors believe will enhance the ability to develop and launch brands in a relatively short timeframe whilst continuing to implement a licensing strategy. The primary focus for the Enlarged Group will be the development of Sirco and the Board will conduct a review of the Altu brand following Admission. 11. Terms of the Acquisition Under the terms of the Acquisition Agreement, the Company has conditionally agreed to acquire Provexis in consideration for the allotment and issue of the Consideration Shares to the Vendors on completion of the Acquisition. In addition, the Company has conditionally agreed to issue 18,184,524 new Ordinary Shares in satisfaction of the Vendor Loans and 12,000,000 New Ordinary Shares in satisfaction of the New Loans. The Consideration Shares will represent 44.73 per cent. of the Enlarged Share Capital of the Company on Admission. The new Ordinary Shares issued pursuant to the conversion of the Vendor Loans and the New Loans will represent 12.09 per cent. of the Enlarged Share Capital of the Company on Admission. The Acquisition Agreement is conditional, inter alia, upon the approval of the Resolutions by Shareholders and completion of the Placing and Admission. 12. Use of Funds The proceeds of the Placing and the New Loans net of the total anticipated costs and expenses of the Placing and Admission, will be approximately £3.6 million which will be applied principally as follows: * the launch and marketing of Sirco in the UK and to secure an international licensing deal for the CardioFlow technology in a beverage format; * to continue to develop the medical food for the dietary management of inflammatory bowel disease, specifically Crohn's disease; * to continue to develop the near-term product pipeline (subject to satisfactory conclusion of negotiations with development partners); and * to fund working capital. 13. The City Code on Takeovers and Mergers Following Completion of the Proposals, the Vendors will between them hold in excess of 50 per cent. of the Enlarged Share Capital of the Company and for so long as they continue to be treated as acting in concert, may accordingly increase their aggregate shareholding without incurring any further obligation under Rule 9 of the City Code to make a general offer for the Company. The Panel should be consulted, however, before any individual member of the Concert Party increases his holding to 30 per cent. or more or, if such holding is already not less than 30 per cent. (but not more than 50 per cent.), before any increase of such holding. 14. Directors, Senior Management and the Scientific Advisory Board of the Enlarged Group The Board of the Enlarged Group will initially comprise two executive Directors and two non-executive Directors. Directors On Completion, the Proposed Directors will be appointed to the Board. Biographical details of the Directors and the Proposed Directors and their positions on the Board on Completion are as follows: Dawson Buck, Non-Executive Chairman, Age 58. Dawson has over twenty years' experience within the UK, US and international electronic security, property, retail and IT industries, holding management, director and officer positions during that time. He joined ANGLE Technology Limited in 2000 and is a director of ANGLE plc. Dr Neville Bain, Non-Executive Deputy Chairman, Age 64. Neville is currently Chairman of Hogg Robinson plc, non-executive director of Scottish & Newcastle plc and a member of the Council of the Institute of Directors and Chairman of their Audit Committee. Dr Stephen Franklin, Chief Executive, Age 37. Stephen has been Chief Executive of Provexis since September 2002. Prior to this, Stephen was a Principal Executive with ANGLE plc and was the primary architect of Protengy, ANGLE's new company creation process Stephen Moon, Commercial Director, Age 48. Stephen has had a career in manufacturing and supply chain roles with BP, Dalgety and Quaker. He joined Nutrinnovator in February 2003. The Company does not currently have a Finance Director but the Board will keep this under review and will seek to appoint a part-time Finance Director when appropriate. Senior Management The senior management team comprises: Fiona Vigar, Director of Marketing; Ian Houghton, Director of Sales; Benedict Hopkins, Director of Operations and Financial Controller; and Niamh O'Kennedy, Principal Scientist. Scientific Advisory Board The Scientific Advisory Board comprises: Professor Asim Dutta-Roy. Asim discovered the anti-aggregatory effect of the tomato extract whilst undertaking research at the Rowett Institute. He is Chairman of the Provexis Scientific Advisory Board and currently Professor of Nutrition at the Institute for Nutrition Research, University of Oslo. Professor David Richardson. David advises Provexis in the field of health claims and functional food regulation. David was formerly Group Chief Scientist with Nestle UK Ltd., and is currently Visiting Professor at the University of Newcastle upon Tyne and University of Reading. Professor David Webb. David is the Christison Professor of Therapeutics & Clinical Pharmacology in the College of Medicine & Veterinary Medicine of the University of Edinburgh. David is also Leader of the University's Centre for Cardiovascular Science. Professor Iain Broom. Iain is a research Professor in Clinical Biochemistry and Metabolic Medicine at Robert Gordon University in Aberdeen. 15. Dividend policy The Directors and the Proposed Directors currently intend to apply the Enlarged Group's cash resources to invest in the growth of its operations and therefore do not anticipate paying dividends in the near future. They will reconsider the Company's dividend policy as and when the Company is in a position to pay dividends. The declaration and payment by the Company of any dividends will depend on the results of the Enlarged Group's operations, its financial condition, cash requirements, future prospects, profits available for distribution and other factors deemed to be relevant at the time. 16. Change of Company name In view of the size and nature of the Acquisition, it is proposed that, on Admission, the name of the Company be changed to Provexis plc. 17. Capital Reorganisation Conditional upon and with effect from Admission, the Company proposes to reorganise its ordinary shares of 2p each so that every 1 ordinary share of 2 pence each will be sub-divided into 2 Ordinary Shares of 1 penny each. No fractional entitlements will arise on the sub-division. As a result of the sub-division the 16,609,194 Existing Ordinary Shares in issue at the date of this announcement will be replaced with 33,218,388 Ordinary Shares. 18. Change of Provexis' financial year end Provexis has an accounting reference date of 30 April, whereas the Company has a financial year end of 31 March. The Directors and the Proposed Directors believe that the Enlarged Group's financial year end should coincide with that of Nutrinnovator. Consequently, the Enlarged Group will report its first audited results for the year ending 31 March 2006. 19. Change of Nominated Adviser and Broker The Company also announced today that Oriel Securities Limited will resign as the Company's nominated adviser and broker with effect from Admission. In their place, the Company will appoint Arbuthnot Securities Limited as its nominated adviser and broker from Admission. 20. Details of the Placing The Company is proposing to raise approximately £3.8 million (before expenses) through a conditional placing by Arbuthnot of 67,424,000 new Ordinary Shares at 5.6 pence per share. The Placing Shares will represent approximately 27.01 per cent. of the Enlarged Share Capital of the Company following Admission. On Admission, it is expected that the Company will have a market capitalisation at the Placing Price of approximately £14.0 million. Arbuthnot has agreed to subscribe approximately £260,000 as part of the Placing. Under the Placing Agreement, Arbuthnot has agreed to use its reasonable endeavours to procure subscribers for the Placing Shares at the Placing Price and has conditionally placed all of these shares at the Placing Price with institutional and certain other investors. The obligations of Arbuthnot under the Placing Agreement are conditional upon, inter alia, Admission taking place by 8.00 a.m. on 23 June 2005 (or such later date, being not later than 8.00 a.m. on 7 July 2005, as the Company and Arbuthnot shall agree). The Placing Agreement contains provisions entitling Arbuthnot to terminate the Placing Agreement at any time prior to Admission in certain circumstances. If this right is exercised, the Placing will lapse and the Acquisition will not take place. The Placing has not been underwritten by Arbuthnot. The Company has applied to the Inland Revenue for provisional clearance that the Placing Shares placed with VCTs will constitute a qualifying holding for such VCT purposes and the Placing Shares will be eligible shares for EIS purposes. The Placing Shares will, on Admission, rank pari passu in all respects with the Existing Ordinary Shares, including the right to receive all dividends and other distributions thereafter declared, made or paid in respect of the ordinary share capital of the Company. 21. Conversion of Loans The Company is proposing to issue 18,184,524 new Ordinary Shares at the Placing Price per share in satisfaction of the Vendor Loans and 12,000,000 new Ordinary Shares at the Placing Price per share in satisfaction of the New Loans, pursuant to the terms of the Acquisition Agreement and 7,142,857 new Ordinary Shares at the Placing Price per share in satisfaction of the Nutrinnovator Loans. 22. Lock-in Arrangements Under the terms of the Placing Agreement, the Directors and the Proposed Directors have agreed with Arbuthnot and the Company not to sell, transfer or otherwise dispose of any interest in any Ordinary Shares held by them immediately following Admission, other than in certain limited circumstances, for a period of 12 months following Admission pursuant to rule 7 of the AIM Rules. The Directors and the Proposed Directors have also agreed that any sale or disposal of Ordinary Shares will be effected through Arbuthnot for such time as it remains the Company's broker and/or nominated adviser under the AIM Rules and offers competitive terms for such sale or disposal. In addition, the Vendors and certain individuals have agreed with Arbuthnot and the Company not to sell, transfer or otherwise dispose of any interest in any Ordinary Shares held by them immediately following Admission, other than in certain limited circumstances for a period of 12 months following Admission pursuant to rule 7 of the AIM Rules. They have also agreed that any sale or disposal of Ordinary Shares will be effected through Arbuthnot for such time as it remains the Company's broker and/or nominated adviser under the AIM Rules and offers competitive terms for such sale or disposal. The lock-in arrangements outlined above will apply in respect of 161,541,079 Ordinary Shares representing approximately 64.7 per cent. of the Enlarged Share Capital. 23. Undertakings An Irrevocable Undertaking has been received from Stephen Moon in respect of the 3,000,000 Existing Ordinary Shares held by him which, at the date of this announcement, represents approximately 18.06 per cent. of the issued share capital of the Company to vote in favour of the Resolutions. Irrevocable Undertakings have also been received from certain shareholders including Fiona Vigar in the Company in respect of the 9,660,795 Existing Ordinary Shares in aggregate held by them which, at the date of this announcement, represent approximately 58.17 per cent. of the issued share capital of the Company to vote in favour of the Resolutions. The Irrevocable Undertakings also contain certain restrictions on dealings in shares until the conclusion of the EGM (or any adjournment thereof). The Irrevocable Undertakings (and the dealing restrictions referred to therein) apply save in certain limited circumstances, including in connection with a takeover offer, the ability to accept an offer, to give irrevocable undertakings to accept an offer and to sell to an offeror or potential offeror who has been named in an announcement pursuant to the City Code, with the exception of the Irrevocable Undertakings entered into by Stephen Moon and Fiona Vigar where these limited circumstances do not apply. The Panel has deemed that Stephen Moon and Fiona Vigar are acting in concert for the period of the Irrevocable Undertakings until the conclusion of the EGM (or any adjournment thereof). 24. Extraordinary General Meeting An Extraordinary General Meeting, notice of which is set out in the Prospectus, will be held at the offices of Charles Russell LLP, 8-10 New Fetter Lane, London EC4A 1RS at 10.00 a.m on 20 June 2005 at which the Resolutions will be proposed to approve the Waiver, to approve the Capital Reorganisation and to approve the Acquisition, increase the authorised share capital of the Company, authorise the Directors to allot shares, disapply statutory pre-emption rights and change the name of the Company and to approve the establishment of a new share option scheme. 25. Prospectus The Company has published a Prospectus in connection with the above proposals which has been sent to Nutrinnovator shareholders together with a Form of Proxy for use at the EGM. A copy of the Prospectus is available from the Company's registered office. 26. Restoration of shares to trading Following the suspension of trading in the Company's shares as referred to above, trading in the Company's shares will re-commence from 8.00am today. EXPECTED TIMETABLE OF PRINCIPAL EVENTS Latest time and date for receipt of the Forms of Proxy for the Extraordinary General Meeting 10.00 a.m. on 18 June 2005 Extraordinary General Meeting 10.00 a.m. on 20 June 2005 Completion date of the Acquisition 23 June 2005 Record date for the Capital Reorganisation 8.00 a.m. on 23 June 2005 Admission of the Ordinary Shares, including the New Ordinary Shares, and dealings commence in the Enlarged Share Capital on AIM 8.00 a.m. on 23 June 2005 DEFINITIONS AND GLOSSARY 'Acquisition' the proposed acquisition of the entire issued share capital of Provexis by the Company, pursuant to the Acquisition Agreement 'Acquisition Agreement' the conditional agreement dated 25 May 2005 between (1) the Company and (2) the Vendors pursuant to which the Company has conditionally agreed to acquire the entire issued share capital of Provexis 'Acting in Concert' shall bear the same meaning ascribed thereto in the City Code 'Admission' the admission of the issued Ordinary Shares and the New Ordinary Shares to trading on AIM becoming effective in accordance with the AIM Rules 'AIM' the AIM Market operated by the London Stock Exchange 'AIM Rules' the rules of AIM governing admission to and the operation of AIM for AIM companies and their nominated advisers as published by the London Stock Exchange from time to time 'ANGLE' ANGLE plc or, where the context admits, any of its relevant subsidiaries 'Arbuthnot' Arbuthnot Securities Limited 'Articles' the Company's articles of association 'Board' the Board of Directors 'Capital Reorganisation' the proposed sub-division of the issued ordinary shares of 2p each in the capital of the Company at Admission and the unissued ordinary shares of 2p each in the capital of the Company into two Ordinary Shares 'Code' or 'City Code' the City Code on Takeovers and Mergers published by the Panel 'Company' or 'Nutrinnovator' Nutrinnovator Holdings plc 'Completion' completion of the Acquisition 'Concert Party' the Vendors 'Consideration Shares' the 111,658,555 new Ordinary Shares to be issued to the Vendors pursuant to the Acquisition Agreement 'CVD' cardiovascular disease 'Directors' the existing directors of the Company 'EGM' or 'Extraordinary the extraordinary general meeting of the General Meeting' Company to be held at 'Enlarged Group' the Group and Provexis following the Acquisition 'Enlarged Share Capital' the Ordinary Shares in issue immediately following Admission as enlarged by the issue of the New Ordinary Shares 'Existing Ordinary Shares' the ordinary shares of 2 pence each in the capital of the Company which will, following the Capital Reorganisation, be each divided into 2 Ordinary Shares 'Existing Shareholders' the Shareholders immediately prior to Admission 'Form of Proxy' the form of proxy for use at the Extraordinary General Meeting 'Group' Nutrinnovator and its subsidiary undertakings 'Irrevocable Undertakings' the irrevocable undertakings dated on or around 13 May 2005 entered into by certain Shareholders in which they have undertaken (subject to certain limited exceptions) to vote in favour of the Resolutions 'Loans' the Nutrinnovator Loans, the Vendor Loans and the New Loans 'London Stock Exchange' London Stock Exchange plc 'New Loans' certain loans made to Provexis on 25 May 2005 'New Ordinary Shares' the Consideration Shares, the Placing Shares and the 37,327,381 new Ordinary Shares issued on conversion of the Loans 'New Share Option Scheme' the Provexis 2005 Unapproved Share Option Scheme proposed to be adopted at the EGM 'North West Equity Fund' North West Equity Fund Limited Partnership acting by its general partner, North West Equity Fund Managers Limited 'Nutrinnovator Loans' the convertible loan notes 'Ordinary Shares' the proposed ordinary shares of 1p each in the capital of the Company following the Capital Reorganisation and 'Ordinary Share' shall be construed accordingly 'Panel' The Panel on Takeovers and Mergers 'Placees' the subscribers of Placing Shares pursuant to the Placing 'Placing' the conditional placing by Arbuthnot on behalf of the Company of the Placing Shares, pursuant to the Placing Agreement 'Placing Agreement' the conditional agreement dated 25 May 2005 between (1) the Company, (2) the Directors and the Proposed Directors, (3) certain Provexis shareholders and (4) Arbuthnot, relating to the Placing 'Placing Price' 5.6p per Placing Share 'Placing Shares' the 67,424,000 new Ordinary Shares to be subscribed for by Placees pursuant to the Placing 'POS Regulations' the Public Offers of Securities Regulations 1995, as amended 'Progeny' Progeny BioVentures Limited 'Proposed Directors' the proposed directors of the Company 'Proposals' the proposals set out in the Prospectus including those which require the approval of Shareholders at the EGM including the Acquisition, the Placing, the conversion of the Loans and the change of name of the Company to Provexis plc 'Prospectus' the Prospectus published by the Company on 25 May 2005 in connection with the Proposals 'Provexis' Provexis Limited 'Provexis Directors' the directors of Provexis 'Provexis Shares' all the issued and to be issued shares in the following classes of share in Provexis: ordinary shares of 100p each; 'A1' ordinary shares of 100p each; deferred shares of 100p each; and redeemable shares of 100p each 'Resolutions' the resolutions contained in the notice of the EGM set out in the Prospectus 'Rule 9' rule 9 of the City Code 'Shareholders' holders of Existing Ordinary Shares 'UK' the United Kingdom of Great Britain and Northern Ireland 'VCT' venture capital trust 'Vendor Loans' the loans summarised in sub-paragraphs (d), (e), (h) and (i) of paragraph 12.2.1 and paragraphs 12.2.2 and 12.2.3 of the Prospectus 'Vendors' ANGLE and the shareholders of Provexis 'Waiver' the waiver of the obligations that would otherwise arise under Rule 9 of the Code for the Concert Party to make a general cash offer for the whole of the Company's issued share capital This information is provided by RNS The company news service from the London Stock Exchange ASDSEFE

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