Statement re Placing

Phytopharm PLC 25 February 2004 25 February 2004 Not for release, publication or distribution in, or into, the United States, Canada, Australia or Japan Phytopharm plc Placing raises £6.5 million Phytopharm plc ('Phytopharm' or the 'Company') today announces that it has raised approximately £6.5 million before expenses (£6.3 million after expenses) through a placing of new shares. The placing was oversubscribed and the proceeds will be used to strengthen the Company's balance sheet and continue the development of its products. Phytopharm's lead programmes in development are P57 for obesity and P58 for Alzheimer's disease. The Company is currently in discussions with a number of potential partners to progress the development of P57 for the dietary control of obesity. A substantial expansion of the raw material production capacity is underway. Phytopharm continues to develop its other lead development programme P58 with its partner Yamanouchi. A product from this programme (PYM50028) entered Phase II studies in December 2003 and is expected to report initial safety results in the second half of 2004, following which the Company anticipates receiving further milestone payments from Yamanouchi. Phytopharm also has two programmes, P7v for canine atopic dermatitis and P54v for canine arthritis, with products that are anticipated to launch in the UK during the first half of 2004. The placing of 3,882,218 new ordinary shares of 1 penny each represents 9.99 per cent of the Company's issued share capital prior to the placing. The new shares have been placed with a range of institutional investors by Nomura International plc and Canaccord Capital (Europe) Ltd at a placing price of 167 pence per share. The placing price represents a discount of approximately 7.2 per cent to the closing middle market price on the London Stock Exchange on 24 February 2004. This placing was undertaken pursuant to a resolution of shareholders at the Company's Annual General Meeting on 23 February 2004 which approved the disapplication of shareholders' pre-emption rights in relation to 10 per cent of the then issued share capital of the Company. Application will be made today for the new shares to be admitted to the Official List and to trading on the London Stock Exchange. The placing is conditional on admission, which is expected to become effective on 1 March 2004. When issued, the new shares will rank pari passu in all respects with the Company's existing ordinary shares. Following the placing, Phytopharm will have a total of 42,743,269 ordinary shares in issue. Enquiries: Phytopharm plc Tel: +44 (0)1480 437 697 Dr. Richard Dixey, Chief Executive Officer Dr Wang Chong, Chief Financial Officer Nomura International plc Tel: +44 (0)20 7521 2000 David Rasouly John Milad Financial Dynamics Tel: +44 (0)20 7831 3113 David Yates Ben Atwell BACKGROUND INFORMATION Phytopharm is a leading company in the development of Botanical pharmaceuticals. These plant-based medicines, manufactured to pharmaceutical standards, can be clinically evaluated in chronic and poorly understood diseases. Where novel modes of action are discovered, such research can form the basis for drug discovery platforms, which enable the development of new medicines and the isolation of single chemical entities of clinical importance. Phytopharm has four drug discovery platforms in full development, for metabolic disease, neurodegeneration, inflammation and dermatology. Phytopharm is developing nine programmes based on its four drug discovery platforms alongside a number of other projects in early evaluation. More information concerning Phytopharm's activities can be found on its web site at http://www.phytopharm.com This information is provided by RNS The company news service from the London Stock Exchange

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