Directorate

PHYTOPHARM PLC 12 August 1999 APPOINTMENT OF MEDICAL DIRECTOR Phytopharm plc (PYM: London Stock Exchange) ('Phytopharm') is pleased to announce the appointment of Dr Rob Grover as Medical Director of the Group. Dr Grover will replace Dr Ian Rubin who is leaving the Company today to become Chief Executive of a new drug development company. Dr Grover, Senior Clinical Research Physician at Glaxo Wellcome, is a Fellow of the Royal College of Anaesthetists with a broad experience of clinical medicine. At Glaxo Wellcome he was leader of an international product development team responsible for a global development programme which included phase I to phase III clinical studies conducted in 28 countries worldwide. He is also experienced in lead compound evaluation and strategic planning to achieve optimisation of product value. Dr Grover will join Phytopharm on September 20th 1999. Richard Dixey, Chief Executive of Phytopharm, said: 'Phytopharm has six products in clinical evaluation so Rob's experience of managing all the clinical phases of drug development in the pharmaceutical sector will be invaluable. We are very pleased to have attracted someone of this calibre to our business. On behalf of everyone at Phytopharm, I would like to express our sincere thanks to Ian for his contribution over the past three years and we wish him well in his new position.' Enquiries: Phytopharm plc Tel: 0498 583754 Dr Richard Dixey, Chief Executive Financial Dynamics Tel: 0207 831 3113 David Yates / Sophie Pender-Cudlip NOTES TO EDITORS Phytopharm plc Phytopharm's business is to take both simple and complex mixtures derived from plant sources into full pharmaceutical development. The US Food and Drug Administration call such medicinal products 'botanicals'. Botanical products are whole or partially purified extracts of medicinal plants in which the chemical composition is not fully characterised. These products represent a new sector in the pharmaceutical market. Phytopharm is the leading company in the development of botanical pharmaceuticals. It has developed a portfolio of 11 such products, six of which are in the clinical evaluation phase. These products have been targeted in the four therapeutic categories of anti-inflammatory treatments, neurological disorders, dermatology and metabolic diseases. In 1997, Phytopharm was granted an Investigational New Drug (IND) approval in the US, the first time an IND has been granted for a complex botanical product, indicating that such products may be registered as prescription medicines. More information concerning Phytopharm's activities can be found on its Web site at http://www.phytopharm.co.uk.

Companies

Ixico (IXI)
UK 100

Latest directors dealings