Director Shareholding

GlaxoSmithKline PLC
18 September 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

17         Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
September  Employee Trust ('the Trust'), purchased 290,416 Ordinary Shares in
2001       the Company at a price of £17.318632 per share, and transferred 9,056
           Ordinary Shares to participants of the Glaxo Wellcome International
           Share Option Scheme and the Glaxo Wellcome UK Share Option Scheme.


The Company was advised of these transactions on 18 September 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.


S M Bicknell

Company Secretary



18 September 2001