Publication of clinical trial

Deltex Medical Group PLC 04 October 2006 Deltex Medical Group plc Publication of clinical trial using SupraQ(TM) to compare different approaches to epidural anaesthesia in women undergoing caesarean delivery 4 October 2006 - Deltex Medical Group plc ('Deltex Medical' or the 'Company'), the UK's leading haemodynamic monitoring company, today announces the publication of a randomised, controlled clinical trial comparing two approaches to epidural anaesthesia in women undergoing elective caesarean delivery. The results were published in the medical journal Anesthesia and Analgesia. Doctors at the Royal Free Hospital in London, under the leadership of Dr Roshan Fernando, used Deltex Medical's SupraQ monitor to look at haemodynamic stability during epidural anaesthesia. The SupraQ was chosen because it is wholly non-invasive and can provide doctors with information about a patient's haemodynamic status that previously was only available using invasive monitoring technology. These more invasive systems were felt to pose too great a risk of complications to be appropriate for use in these healthy patients. Traditional measures of haemodynamic status like blood pressure and heart rate are insufficiently sensitive to detect changes in haemodynamic status early enough to be of value. This trial is the first to compare the changes in haemodynamic status caused by these two methods of delivering epidural anaesthesia. The aim of the trial was to test the impact of the different approaches to anaesthetic delivery on haemodynamic stability in order to better inform medical research and the development of improved anaesthetic protocols for patients undergoing caesarean delivery. Dr Fernando commented: 'The results of this trial will prove invaluable in improving the management of high-risk patients presenting for caesarean section, such as those with significant cardiovascular disease.' Deltex Medical's chief executive, Andy Hill, commented: 'This trial confirms the need and potential for a wholly non-invasive haemodynamic monitor that can provide doctors with the same reliable, high-quality data, in real-time, as the CardioQ. The SupraQ allowed Dr Fernando and his collaborators to measure changes in key indicators of cardiac function as they happened, something that more invasive and potentially risky alternatives cannot do.' For further information, please contact: Deltex Medical Group plc 01243 774 837 Nigel Keen, Nigel Chairman Andy Hill, Chief Executive Ewan Phillips, Finance Director Gavin Anderson & Company 020 7554 1400 Deborah Walter Marie Cairney Jodie Reilly Charles Stanley Securities 020 7149 6457 Philip Davies Notes for Editors Deltex Medical manufactures and markets the CardioQ monitor, which uses disposable ultra-sound probes inserted into the oesophagus to determine the amount of blood being pumped around the body - 'circulating blood volume'. Reduced circulating blood volume is known as hypovolaemia, which leads to insufficient oxygen being delivered to the organs. This causes medical complications including peripheral and major organ failure which can lead to death. Hypovolaemia, which is akin to severe dehydration, affects virtually every patient having surgery because of the combined effects of pre-operative starvation, the impact of the anaesthetic agents and trauma from the surgery itself. Using fluids and drugs, guided by the CardioQ, to optimise the amount of circulating blood significantly reduces post-operative complications allowing patients to make a faster, more complete recovery and return home earlier. The CardioQ incorporates the Company's proprietary software and a small diameter, easy-to-use, minimally invasive, disposable oesophageal probe that is used for transmitting and receiving an ultra-sound signal. By using this technology, the CardioQ provides clinicians with the ability to haemodynamically optimise critically ill patients and those undergoing routine moderate to major surgery through the controlled administration of fluid and drugs. Haemodynamic optimisation has been scientifically proven to improve the speed and quality of patient recovery and reduce hospital stay. There are already over 1,250 CardioQs currently in use in hospitals worldwide and distribution arrangements are in place in over 30 countries. In addition, there are currently more than 90 clinical publications on the use of the CardioQ which have repeatedly: •Validated the results of the Monitor against known standards for measuring cardiac output, demonstrating that the technology works •Proved that the CardioQ works in a wide range of surgical procedures •Demonstrated that the Company's technology provides significant health and economic benefits by helping to reduce post-operative complications and length of hospital stays by an average of 30 to 40 per cent for a wide range of patients. This information is provided by RNS The company news service from the London Stock Exchange
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