Publication of clinical study

Deltex Medical Group PLC 04 January 2007 Deltex Medical Group plc New study demonstrates fundamental technological advantages of CardioQ(TM) 4 January 2007 Deltex Medical Group plc ('Deltex Medical' or the 'Company'), the UK's leading haemodynamic monitoring company, today announces the publication by a leading scientific journal of a clinical study comparing multiple, alternative haemodynamic monitoring technologies to the CardioQ in patients undergoing surgery. Dr Bundgaard-Neilsen and colleagues at University Hospital, Copenhagen carried out the study as part of Professor Henrik Kehlet's 'fast-track' surgery research programme. The aim of the study was to determine whether a fluid management protocol using the CardioQ, the only haemodynamic monitor proven to improve outcomes in multiple clinical trials, could be replicated using alternative technologies. During the study, patients were given fluid, guided by the CardioQ, using a standard protocol. Changes in the parameters measured by a variety of monitoring technologies were recorded simultaneously and compared to changes seen with the CardioQ. The results of the study showed that there were no significant changes in blood pressure during fluid delivery. There were also no significant changes in blood-oxygen levels during fluid delivery when these were measured in muscle or the brain and, although centrally measured blood-oxygen levels did increase during fluid delivery, these could not be used as a guide to optimisation when compared to the CardioQ. Heart rate decreased as patients were optimised, as would be expected from earlier clinical studies, but this is of little value in fluid management. The pressure-based cardiac output monitoring technology used in the study was either unable to detect the magnitude of change seen by the CardioQ or unable to detect those changes as quickly as the CardioQ. The study is published in the January edition of the British Journal of Anaesthesia. The abstract of the paper is available online at http://bja.oxfordjournals.org/cgi/content/abstract/98/1/38 where the full paper is also available to subscribers. Deltex Medical's chief executive, Andy Hill, commented: 'In over 80% of patients in this study the chosen pressure-based cardiac output monitoring system either suggested that the patient was 'optimised' when the CardioQ clearly showed a requirement for significantly more fluid or vice versa. Based on these results it would be impossible to use this kind of system to follow the intra-operative fluid delivery protocol that has been repeatedly demonstrated in studies with the CardioQ to reduce complications and shorten length of stay. In the absence of clinical evidence supporting any alternative approaches, the CardioQ clearly must be considered the de facto standard of care for fluid management in patients having surgery.' For further information, please contact:- Deltex Medical Group plc 01243 774 837 Nigel Keen, Chairman nk@deltexmedical.com Andy Hill, Chief Executive ah@deltexmedical.com Ewan Phillips, Finance Director ep@deltexmedical.com Gavin Anderson & Company 0207 554 1400 Marie Cairney mcairney@gavinanderson.co.uk Jodie Reilly jreilly@gavinanderson.co.uk Charles Stanley Securities 020 7149 6457 Philip Davies philip.davies@csysecurities.com Notes for Editors Deltex Medical manufactures and markets the CardioQ monitor, which uses disposable ultra-sound probes inserted into the oesophagus to determine the amount of blood being pumped around the body - 'circulating blood volume'. Reduced circulating blood volume is known as hypovolaemia, which leads to insufficient oxygen being delivered to the organs. This causes medical complications including peripheral and major organ failure which can lead to death. Hypovolaemia, which is akin to severe dehydration, affects virtually every patient having surgery because of the combined effects of pre-operative starvation, the impact of the anaesthetic agents and trauma from the surgery itself. Using fluids and drugs, guided by the CardioQ, to optimise the amount of circulating blood significantly reduces post-operative complications allowing patients to make a faster, more complete recovery and return home earlier. The CardioQ incorporates the Company's proprietary software and a small diameter, easy-to-use, minimally invasive, disposable oesophageal probe that is used for transmitting and receiving an ultra-sound signal. By using this technology, the CardioQ provides clinicians with the ability to haemodynamically optimise critically ill patients and those undergoing routine moderate to major surgery through the controlled administration of fluid and drugs. Haemodynamic optimisation has been scientifically proven to improve the speed and quality of patient recovery and reduce hospital stay. There are already over 1,250 CardioQs currently in use in hospitals worldwide and distribution arrangements are in place in over 30 countries. In addition, there are currently more than 90 clinical publications on the use of the CardioQ which have repeatedly:- •Validated the results of the Monitor against known standards for measuring cardiac output, demonstrating that the technology works •Proved that the CardioQ works in a wide range of surgical procedures •Demonstrated that the Company's technology provides significant health and economic benefits by helping to reduce post-operative complications and length of hospital stays by an average of 30 to 40 per cent for a wide range of patients. This information is provided by RNS The company news service from the London Stock Exchange
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