Product Update

Deltex Medical Group PLC 04 May 2005 Deltex Medical Group plc CardioQ reduces hospital stay by 2 days in colorectal surgery patients 4 May 2005: Deltex Medical Group plc ('Deltex Medical' and the 'Company'), today announces the results of a double-blinded prospective randomised controlled clinical trial using its CardioQ(TM) haemodynamic monitoring system on post-operative colorectal patients. The trial was undertaken by surgeons and anaesthetists at the Freeman Hospital in Newcastle-upon-Tyne. The first results to come from the study were presented this week at the American Society of Colon and Rectal Surgeons meeting in Philadelphia. In the trial 108 patients undergoing elective colorectal surgery were divided into two groups of 54 each. The control group were given fluids peri-operatively at the anaesthetist's discretion whereas the treatment group were given fluids based on an algorithm guided by the CardioQ. The statistically significant results of the study presented in Philadelphia included a reduction in major post surgical complications in the CardioQ group with only 1% of patients suffering such a complication compared to 13.7% in the control group. The average (median) hospital stay was seven days for CardioQ patients compared to nine days in the control group. Further details are expected to be given at future clinical meetings and on publication of the full study results. The trial concluded that fluid optimisation using the CardioQ leads to shorter hospital stays and a decrease in major morbidity with consequent major implications for the management of patients in fast-track regimens. Deltex Medical's Chief Executive, Andy Hill commented: 'The results of this study have a number of important implications for the Company. The study adds to the substantial amount of positive evidence supporting the use of the CardioQ in moderate and major surgery in general and, following a similar study from Worthing Hospital announced last September, in colorectal surgery as a stand-alone speciality. This allows us to market the benefits of the CardioQ in the treatment of bowel cancer as well as in peri-operative anaesthesia. 'As the study was the first one using the CardioQ to be led by surgeons rather than anaesthetists, its findings should reach a wider audience than previous studies at a time when colorectal surgeons are being increasingly scrutinised with regard both to the quality of outcome for their patients and the total cost of the patient's surgery and hospital stay.' For further information, please contact:- Deltex Medical Group plc 01243 774 837 Nigel Keen, Chairman Andy Hill, Chief Executive Ewan Phillips, Finance Director Financial Dynamics 0207 831 3113 David Yates Lucy Briggs Notes for Editors Deltex Medical manufactures and markets the CardioQ monitor, which uses disposable ultra-sound probes inserted into the oesophagus to determine the amount of blood being pumped around the body - 'circulating blood volume'. Reduced circulating blood volume is known as hypovolaemia, which leads to insufficient oxygen being delivered to the organs. This causes medical complications including peripheral and major organ failure which can lead to death. Hypovolaemia, which is akin to severe dehydration, affects virtually every patient having surgery because of the combined effects of pre-operative starvation, the impact of the anaesthetic agents and trauma from the surgery itself. Using fluids and drugs, guided by the CardioQ, to optimise the amount of circulating blood significantly reduces post-operative complications allowing patients to make a faster, more complete recovery and return home earlier. The CardioQ incorporates the Company's proprietary software and a small diameter, easy-to-use, minimally invasive, disposable oesophageal probe that is used for transmitting and receiving an ultra-sound signal. By using this technology, the CardioQ provides clinicians with the ability to haemodynamically optimise critically ill patients and those undergoing routine moderate to major surgery through the controlled administration of fluid and drugs. Haemodynamic optimisation has been scientifically proven to improve the speed and quality of patient recovery and reduce hospital stay. There are already over 1,250 CardioQs currently in use in hospitals worldwide and distribution arrangements are in place in over 30 countries. In addition, there are currently more than 90 clinical publications on the use of the CardioQ which have repeatedly:- • validated the results of the Monitor against known standards for measuring cardiac output, demonstrating that the technology works • proved that the CardioQ works in a wide range of surgical procedures • demonstrated that the Company's technology provides significant health and economic benefits by helping to reduce post-operative complications and length of hospital stays by an average of 30 to 40 per cent for a wide range of patients. This information is provided by RNS The company news service from the London Stock Exchange
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