Positive Scientific Review

Deltex Medical Group PLC 23 January 2008 Deltex Medical Group plc Positive scientific review of CardioQ technology published 23 January 2008 - Deltex Medical Group plc ('Deltex Medical'), the UK's leading haemodynamic monitoring company, today announces the results of a new review of the CardioQ(TM) technology of oesophageal Doppler monitoring (ODM). The paper from doctors at the University of Auckland in New Zealand was published in the journal Anaesthesia and assesses, using the technique of meta-analysis, the clinical evidence for the use of ODM in abdominal surgery. Meta-analysis (a systematic scientific review which considers related evidence as a whole) is used heavily by doctors within clinical circles to determine technologies and interventions which should be established as standards of care. The meta-analysis concluded that 'Pooled analysis showed a reduced hospital stay in the intervention group. Overall, there were fewer complications and ICU admissions, and less requirement for inotropes (drugs used to enhance the heart's performance) in the intervention group. Return of normal gastro-intestinal function was also significantly faster in the intervention group. Oesophageal Doppler use for monitoring and optimisation of flow-related haemodynamic variables improves short-term outcome in patients undergoing major abdominal surgery.' The full article (S. M. Abbas, A. G. Hill (2008): Systematic review of the literature for the use of oesophageal Doppler monitor for fluid replacement in major abdominal surgery Anaesthesia 63 (1), 44-51) is available to subscribers at http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2044.2007.05233.x Deltex Medical's Chief Executive, Andy Hill commented: 'This is the first meta-analysis on ODM to have been published in a peer-reviewed scientific journal. Its publication only reinforces that the CardioQ is closer than ever before to being widely acknowledged as a standard of care.' For further information, please contact:- Deltex Medical Group plc 01243 774 837 Nigel Keen, Chairman njk@deltexmedical.com Andy Hill, Chief Executive ahill@deltexmedical.com Ewan Phillips, Finance Director eap@deltexmedical.com Gavin Anderson & Company 0207 554 1400 Deborah Walter dwalter@gavinanderson.co.uk Robert Speed rspeed@gavinanderson.co.uk Charles Stanley Securities 020 7149 6000 (Nominated Adviser) Philip Davies philip.davies@csysecurities.com Russell Cook russell.cook@csysecurities.com Notes for Editors Deltex Medical manufactures and markets the CardioQ(TM) monitor, which uses disposable ultra-sound probes inserted into the oesophagus to determine the amount of blood being pumped around the body - 'circulating blood volume'. Reduced circulating blood volume is known as hypovolaemia, which leads to insufficient oxygen being delivered to the organs. This causes medical complications including peripheral and major organ failure which can lead to death. Hypovolaemia, which is akin to severe dehydration, affects virtually every patient having surgery because of the combined effects of pre-operative starvation, the impact of the anaesthetic agents and trauma from the surgery itself. Using fluids and drugs, guided by the CardioQ, to optimise the amount of circulating blood significantly reduces post-operative complications allowing patients to make a faster, more complete recovery and return home earlier. The CardioQ incorporates the Company's proprietary software and a small diameter, easy-to-use, minimally invasive, disposable oesophageal probe that is used for transmitting and receiving an ultra-sound signal. By using this technology, the CardioQ provides clinicians with the ability to haemodynamically optimise critically ill patients and those undergoing routine moderate to major surgery through the controlled administration of fluid and drugs. Haemodynamic optimisation has been scientifically proven to improve the speed and quality of patient recovery and reduce hospital stay. There are already around 1,500 CardioQs currently in use in hospitals worldwide and distribution arrangements are in place in over 30 countries. In addition, there are currently more than 90 clinical publications on the use of the CardioQ which have repeatedly:- •Validated the results of the Monitor against known standards for measuring cardiac output, demonstrating that the technology works •Proved that the CardioQ works in a wide range of surgical procedures •Demonstrated that the Company's technology provides significant health and economic benefits by helping to reduce post-operative complications and length of hospital stays by an average of 30 to 40 per cent for a wide range of patients. The SupraQ(TM) is an entirely non-invasive device which uses an ultrasound probe held at the base of the patient's neck to track the flow of blood in the aorta; it presents the same data as the CardioQ in a similar format and is used for taking snapshots or monitoring over short periods. This information is provided by RNS The company news service from the London Stock Exchange
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