Clinical Trial Results

Deltex Medical Group PLC 31 August 2006 Deltex Medical Group plc Major new trial shows CardioQTM reducing duration of hospital stays by one third 31 August 2006 Deltex Medical Group plc ('Deltex Medical' or the 'Company'), the UK's leading haemodynamic monitoring company, announces the publication today, in the British Journal of Surgery, of the results of a major new clinical trial using its CardioQ oesophageal Doppler monitors. The study conducted at the Freeman Hospital in Newcastle demonstrated that in cases where doctors used Deltex Medical's CardioQ treatment during surgery to help better maintain fluid balance and blood circulation, those patients suffered fewer complications and were fit for discharge three days sooner than those who did not receive the treatment. Specifically, the study's main findings showed that patients using CardioQ: •Were fit for discharge three days sooner (6 days versus 9 days); •Were actually discharged from hospital two days sooner (7 days versus 9 days); •Suffered significantly fewer post-operative complications (2% of patients versus 15%); •Did not require unplanned intensive care (0% versus 11% of patients in the control group); and •Tolerated food significantly earlier (2 days versus 4 days after surgery). The double-blinded prospective randomised controlled trial followed 108 patients undergoing bowel surgery. Patients being treated under the guidance of the CardioQ monitor were, on average, fit for discharge after six days and actually discharged after seven days. Patients where the CardioQ was not used were, on average, fit for discharge after nine days, three days longer. They were actually discharged after nine days, two days longer. Comparison between today's study and recent NHS data on outcome following major bowel surgery shows that the average length of stay for patients treated at the Freeman Hospital using the CardioQ is almost half that of the NHS average; 7 days compared with 15 days. A day in an NHS general or surgical ward costs up to £400 a day, depending on additional care required; in an intensive care unit it costs £1,200 or more according to the Department of Health published Healthcare Resource Groups (HRGs) reference cost data. The potential productivity gains and financial savings to the NHS from reducing the length of hospital stay are huge. Use of the CardioQ has been proven to reduce length of hospital stay in numerous different surgical specialities including orthopaedic, colorectal, cardiac and general surgery. In evidence submitted to the Health Select Committee on June 2006, the Improving Surgical Outcomes Group (ISOG) estimated that up to one million NHS patients a year could benefit from being treated under the guidance of the CardioQ during surgery. If all NHS patients having major surgery were treated with the CardioQ, the NHS could save between £350 million and £1 billion a year, according to ISOG evidence. Mr Alan Horgan, Consultant Colorectal Surgeon at the Freeman Hospital, leader of the study said: 'These results are remarkable. Everyone involved in surgery and NHS management should read this study. 'Fluid-balance during and after surgery is incredibly important to patient wellbeing. Being able to monitor and maintain balance more accurately with CardioQ has allowed us to take days off patient recovery time. We have proven that it is possible to save the NHS both time and money, while also enhancing patient care.' Deltex Medical's chief executive, Andy Hill, commented: 'CardioQ has now been proven to work in seven independent randomised controlled clinical trials. This study has shown once again that it benefits patients and can deliver dramatic improvements to hospital productivity and financial efficiency. 'In the current climate of financial deficits, embracing this technology should be a no-brainer for the NHS. Fantastic results like this confirm once more that NHS Trusts can both save money and improve patient care through prioritising the adoption of our technology. We are working with large numbers of doctors throughout the UK who are seeking the necessary funding to use the CardioQ as a standard of care and we expect that this study will allow them to push harder than ever before to secure that funding.' For further information, please contact:- Deltex Medical Group plc 01243 774 837 Nigel Keen, Nigel Chairman nigel.keen@deltexmedical.com Andy Hill, Chief Executive andy.hill@deltexmedical.com Ewan Phillips, Finance Director ewan.Phillips@deltexmedical.com Gavin Anderson & Company 0207 554 1400 Deborah Walter dwalter@gavinanderson.co.uk Marie Cairney mcairney@gavinanderson.co.uk Jodie Reilly jreilly@gavinanderson.co.uk Charles Stanley Securities 020 7149 6457 Philip Davies philip.davies@csysecurities.com Notes for Editors Deltex Medical manufactures and markets the CardioQ monitor, which uses disposable ultra-sound probes inserted into the oesophagus to determine the amount of blood being pumped around the body - 'circulating blood volume'. Reduced circulating blood volume is known as hypovolaemia, which leads to insufficient oxygen being delivered to the organs. This causes medical complications including peripheral and major organ failure which can lead to death. Hypovolaemia, which is akin to severe dehydration, affects virtually every patient having surgery because of the combined effects of pre-operative starvation, the impact of the anaesthetic agents and trauma from the surgery itself. Using fluids and drugs, guided by the CardioQ, to optimise the amount of circulating blood significantly reduces post-operative complications allowing patients to make a faster, more complete recovery and return home earlier. The CardioQ incorporates the Company's proprietary software and a small diameter, easy-to-use, minimally invasive, disposable oesophageal probe that is used for transmitting and receiving an ultra-sound signal. By using this technology, the CardioQ provides clinicians with the ability to haemodynamically optimise critically ill patients and those undergoing routine moderate to major surgery through the controlled administration of fluid and drugs. Haemodynamic optimisation has been scientifically proven to improve the speed and quality of patient recovery and reduce hospital stay. There are already over 1,250 CardioQs currently in use in hospitals worldwide and distribution arrangements are in place in over 30 countries. In addition, there are currently more than 90 clinical publications on the use of the CardioQ which have repeatedly:- •Validated the results of the Monitor against known standards for measuring cardiac output, demonstrating that the technology works •Proved that the CardioQ works in a wide range of surgical procedures •Demonstrated that the Company's technology provides significant health and economic benefits by helping to reduce post-operative complications and length of hospital stays by an average of 30 to 40 per cent for a wide range of patients. This information is provided by RNS The company news service from the London Stock Exchange
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