Re Agreement

Cambridge Antibody Tech Group PLC 5 June 2001 01/CAT/10 FOR IMMEDIATE RELEASE 10.00 BST, 05.00 EST Tuesday 5 June 2001 For Further Information Contact: Cambridge Antibody Technology Square Mile BSMG Worldwide (Europe) Tel: +44 (0) 1763 263 233 Tel: +44 (0) 20 7601 1000 David Chiswell, CEO Kevin Smith John Aston, Finance Director Graham Herring Rowena Gardner, Head of Corporate Communications Xerion Pharmaceuticals GmbH BMC Communications/The Trout Group (USA) Tel: +49 (0) 89 89 99 64 0 Tel: 001 212 477 9007 Fritz Rudert, Director of Strategic Alliances and Licensing Brad Miles, ext 17 (media) Alexander Jaksch, Manager, Business Brandon Lewis, ext.15 Development & Marketing (investors) CAMBRIDGE ANTIBODY TECHNOLOGY AND XERION PHARMACEUTICALS ANNOUNCE LICENSING AGREEMENT FOR HUMAN ANTIBODY TECHNOLOGY Melbourn, UK and Martinsried, Germany... Cambridge Antibody Technology (LSE: CAT) and Xerion Pharmaceuticals GmbH today announce an agreement whereby CAT will license its proprietary human phage antibody libraries and underlying intellectual property to Xerion for target discovery, target validation and functional proteomics. CAT receives a licence fee from Xerion in this initial research agreement. Dr. David Chiswell, Chief Executive Officer of CAT, commented 'Xerion is an exciting company with tremendous future potential. CAT has long recognised that one of the major challenges to drug discovery today is effective and efficient validation of the drug targets of tomorrow. We feel that the synergies between CAT's human antibody library technology and Xerion's innovative approach to targeting protein function directly has the potential to build significant future value.' Dr. Markus Ewert, President and Chief Executive Officer of Xerion added, 'We are excited to start this long-term relationship with CAT, a highly successful and advanced company in the field of antibody phage display technologies and development of therapeutic antibodies. CAT's antibody competence and Xerion's XCALIburTM technologies will complement each other exceptionally well and thus create powerful target validation tools.' CAT has alliances with a large number of biotechnology and pharmaceutical companies and has previously licensed its human antibody phage display libraries to several companies, including Genentech, Pfizer, Eli Lilly, Human Genome Sciences and Immunex. Xerion Pharmaceuticals focuses on applying its technological leadership in drug target validation partnerships and building its own pipeline based on novel validated targets. Xerion has a number of its own and partnered initiatives in the drug target discovery area. Its functional proteomics platform directly addresses protein function, enabling target identification and validation through antibody-based strategies and its core proprietary technology, Chromophore Assisted Laser Inactivation (CALI). -ENDS- Notes to Editors: Cambridge Antibody Technology (CAT) CAT is a UK biotechnology company using its proprietary technologies in human monoclonal antibodies for drug discovery and drug development. Based in Melbourn, 10 miles south of Cambridge, England, CAT currently employs around 220 people. CAT is listed on the London Stock Exchange, having raised £41m in its IPO in March 1997. A secondary offering in March 2000 raised £93m. CAT has a world-leading platform technology for rapidly isolating fully human monoclonal antibodies using phage display systems. CAT has an extensive phage antibody library, currently incorporating around 100 billion distinct antibodies. This library forms the basis for the company's strategy to develop a portfolio of clinical development programmes and for discovering new drug leads using functional genomics. Four human therapeutic antibodies developed by CAT are at various stages of clinical trials. CAT has a number of licence and collaborative agreements in place with pharmaceutical and biotechnology companies including: Eli Lilly, Pfizer, BASF Pharma (Abbott), Genentech, ICOS, Genetics Institute, Wyeth-Ayerst, Human Genome Sciences, AstraZeneca, Pharmacia, Oxford GlycoSciences, Genzyme, Immunex, Zyomyx and Elan. Xerion Pharmaceuticals Xerion Pharmaceuticals is a functional proteomics company dedicated to disease target validation. The company is based in Martinsried near Munich, Germany. Xerion Pharmaceuticals has recently completed its second financing round raising EUR11.1 million. Xerion Pharmaceuticals' integrated functional proteomics technology platform (XcelerateTM, XCALIbur TM, X-ploreTM) is focused on efficiently identifying and validating protein drug targets. Xerion is partnering its technology platform with pharmaceutical companies to assist in their drug discovery efforts. At the same time, the technology platform is being applied internally to the identification and validation of potential drug targets. Xerion Pharmaceuticals has license and partnering agreements with TILL Photonics GmbH, MDS Proteomics and several research institutes. This press release contains statements about Cambridge Antibody Technology Group plc (CAT) that are forward looking statements. All statements other than statements of historical facts included in this press release may be forward looking statements These forward looking statements are based on numerous assumptions regarding CAT's present and future business strategies and the environment in which CAT will operate in the future. Certain factors that could cause CAT's actual results, performance or achievements to differ materially from those in the forward looking statements include: market conditions, CAT's ability to enter into and maintain collaborative arrangements, success of product candidates in clinical trials, regulatory developments and competition.
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