Director/PDMR Shareholding

AstraZeneca PLC
07 August 2006

Dealing by Director
Companies Act 1985 Sections 324/329


Transaction by Person Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R

We hereby inform you that on 4 August 2006, John Patterson, a Director of the
Company, exercised options over 45,613 AstraZeneca PLC USD0.25 Ordinary Shares
as follows:


Number of shares   Option price    Name of scheme under which options were granted

10,944             2448p           Zeneca 1994 Executive Share Option Scheme

34,669             2231p           AstraZeneca Share Option Plan


We also inform you that also on 4 August 2006, Dr Patterson sold 9,486 of the
45,613 Ordinary Shares acquired from the exercise at a price of 3185 pence per
share and sold 28,615 of the 45,613 Ordinary Shares acquired from the exercise
at a price of 3182 pence per share.  These sales of shares were effected to
cover the cost of exercising the options and to meet an immediate income tax and
NI liability.  Dr Patterson has retained 7,512 shares.


As a result of these transactions, Dr Patterson holds options over 192,574
Ordinary Shares of AstraZeneca PLC and his interest in the Ordinary Shares of
the Company has increased by 7,512 shares to 88,902 shares, which represents
approximately 0.006% of the issued ordinary capital of the Company.



G H R Musker
Company Secretary
7 August 2006


                      This information is provided by RNS
            The company news service from the London Stock Exchange