Director/PDMR Shareholding

AstraZeneca PLC
18 August 2006


Transaction by Person Discharging Managerial Responsibilities

Disclosure Rules DR 3.1.2R


We hereby inform you that on 17 August 2006, Jan Lundberg, Executive
Vice-President, Discovery Research, a person discharging managerial
responsibilities, exercised options over 71,032 AstraZeneca PLC USD0.25 Ordinary
Shares as follows:


- option over 11,952 shares at an option price of 2714 pence per share


- option over 26,725 shares at an option price of 1913 pence per share


- option over 32,355 shares at an option price of 2231 pence per share


The options were granted to Mr Lundberg under the Company's 1994 Executive Share
Option Scheme and the AstraZeneca Share Option Plan.


We also inform you that on 17 August 2006, Mr Lundberg sold the 71,032 shares
acquired from the exercise at an average price of 3291 pence per share.


G H R Musker

Company Secretary

18 August 2006


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