Half-yearly Report

NEWS RELEASE 30 November 2010 London Stock Exchange Announcement WORLDWIDE HEALTHCARE TRUST PLC (Formerly Finsbury Worldwide Pharmaceutical Trust PLC) Unaudited Interim Report for the six months ended 30 September 2010 COMPANY NAME At the Company's Annual General Meeting, held on 15 July 2010, a Special Resolution was passed to change the Company's name from Finsbury Worldwide Pharmaceutical Trust PLC to Worldwide Healthcare Trust PLC. INVESTMENT OBJECTIVE AND BENCHMARK Worldwide Healthcare Trust PLC invests worldwide in a diversified portfolio of shares in pharmaceutical, biotechnology and related companies in the healthcare sector with the objective of achieving a high level of capital growth. Up until 30 September 2010, performance was measured against the Datastream World Pharmaceutical & Biotechnology Index (total return, sterling adjusted). Following shareholder approval, gained at the Annual General Meeting held on 15 July 2010, the Company's benchmark was changed to the MSCI World Health Care Index (total return, sterling adjusted). The Board agreed with the Company's Investment Manager that the new benchmark would be used for performance comparison purposes with effect from 1 October 2010. INVESTMENT POLICY The Board seeks to manage the Company's risk by imposing various investment limits and restrictions. The limits and restrictions remain unchanged from those published in the annual report for the year ended 31 March 2010. A summary of the key limits and restrictions are as follows: The Company will not invest more than 10% of its gross assets in other UK listed investment companies (including listed investment trusts). It will not invest more than 15% of the portfolio in any one individual stock at the time of acquisition. 60% of the portfolio will normally be invested in larger companies (i.e. with a market capitalisation of at least US$5bn). 20% of the portfolio will normally be invested in smaller companies (i.e. with a market capitalisation of less than US$5bn). Investment in unquoted securities will not exceed 10% of the portfolio at the time of acquisition. Derivative (using options) transactions can be used to mitigate risk or enhance capital returns and exposure will be restricted to 5% of the portfolio. The Company does not hedge its foreign currency exposure. In accordance with the requirements of the UK Listing Authority, any material change to the investment policy will only be made with the approval of shareholders by ordinary resolution. CAPITAL STRUCTURE Shares At 30 September 2010 the Company had in issue 43,385,916 shares of 25p each (30 September 2009: 47,927,769, 31 March 2010: 44,336,756). During the half year, a total of 1,637,733 shares were bought back by the Company for treasury. This equates to 3.7% of the issued share capital as at 31 March 2010. On 27 July 2010, a total of 7,877,149 shares held in treasury were cancelled. The Board has confirmed that any shares held in treasury will be cancelled on or as soon as practicable following the Annual General Meeting each year. At 30 September 2010, no shares were held in treasury. Since the end of the half year a further 103,054 shares have been repurchased for treasury and, as at 26 November 2010, the Company had 43,313,878 shares in issue excluding those shares held in treasury. Subscription Shares During the half year, 686,893 subscription shares were converted into ordinary shares, at an exercise price of 614p per share raising £4.2m. Since the end of the half year a further 31,016 subscription shares were converted into ordinary shares, at an exercise price of 638p per share raising £0.2m. As at 26 November 2010, the Company had 8,274,398 subscription shares in issue. GEARING The Company's gearing policy is that it may borrow up to the lower of £70m or 20% of the Company's net asset value. The Company's borrowing requirements are met through the utilisation of a loan facility, repayable on demand, provided by the Company's custodian, Goldman Sachs & Co. New York. At 30 September 2010, the Company had borrowed £38.5m under this facility, equating to 11.6% of the Company's net assets. CONTINUATION VOTE The next continuation vote of the Company will be held at the Annual General Performance Six months to One year to 30 September 31 March 2010 2010 Share price (total return)# -0.3% +28.7% Net asset value per share (total +0.9% +25.9% return)# Benchmark index (total return)* -3.6% +24.6% 30 September 31 March Six months 2010 2010 % Change Shareholders' funds £331.0m £346.2m -4.4 Net asset value per share - diluted (dilution for subscription shares) 742.9p 752.7p -1.3 Share price 690.0p 701.5p -1.6 Discount of share price to diluted net asset value per share 7.1% 6.8% - Benchmark Index * 9,734.2 10,094.2 -3.6 Gearing ** 11.6% 10.4% - Total expense ratio (excluding performance fees) 1.0% 1.0% - Total expense ratio (including performance fees paid in the 1.1% 1.0 - period) # Source - Morningstar. Net asset value diluted for subscription shares and treasury shares. * Datastream World Pharmaceutical and Biotechnology Index, total return, sterling adjusted. With effect from 1 October 2010 the Company's benchmark has changed to MSCI World Health Care Index, (total return, sterling adjusted). **Calculated using the Association of Investment Companies' definition (prior charges as a percentage of net assets). Chairman's Statement Change of the Company's Name, Investment Policy and Benchmark I am pleased to report that at the Company's Annual General Meeting, held on 15 July 2010, the necessary resolutions were passed to change the Company's name, to amend its investment policy and also to change the Company's benchmark from the Datastream World Pharmaceutical and Biotechnology Index (measured in sterling terms on a total return basis) to the MSCI World Health Care Index (measured in sterling terms on a total return basis). The Board has agreed with your Investment Manager that there should be a period of transition in order to allow them to realign the portfolio to reflect the new investment policy and benchmark. Accordingly, it has been agreed that the new benchmark will be used for performance comparison purposes with effect from 1 October 2010. Performance Following strong performance from markets and the Company during its last financial year, the returns from global markets over the first half of the current financial year were mixed. This was also reflected in the performance of the healthcare sector with the Datastream World Pharmaceutical and Biotechnology Index (measured in sterling terms on a total return basis) falling by 3.6% during the period. By way of comparison, the MSCI World Health Care Index (measured in sterling terms on a total return basis) fell by 5.6% during the same period. This compares to the Company's net asset value total return of +0.9% and a share price total return of -0.3%. The discount of the Company's share price to the Company's diluted net asset value per share widened slightly during the period to close at 7.1% compared to 6.8% six months ago. Our Investment Manager has begun repositioning the portfolio to reflect the Company's amended investment policy and benchmark. Capital The Board regularly reviews its discount policy. The formal discount management policy in place seeks to maintain the discount to the net asset value per share at which the Company's shares are quoted on the London Stock Exchange at no greater than 6% over the long-term, subject to adverse market conditions. There can be no guarantee that the Board's discount policy will always be successful or capable of being implemented. During the six months under review the Company repurchased 1,637,733 shares for treasury at a total cost of £10.9m (including expenses). On 27 July 2010, a total of 7,877,149 shares held in treasury were cancelled. The Board has confirmed that any shares held in treasury will be cancelled on or as soon as practicable following the Annual General Meeting each year. During the period and to the date of this report a total of 686,893 subscription shares were exercised at an exercise price of 614p per share raising £4.2m of additional funds for the Company and a further 31,016 subscription shares were exercised at an exercise price of 638p per share raising £0.2m. The next subscription date will be 31 January 2011 at a subscription price of 638p per share. Revenue and Dividends The revenue return for the period was £2,196,000 (six months ended 30 September 2009: return of 1,175,000) and no interim dividend is declared (six months ended 30 September 2009: nil). Outlook The prospect of healthcare reform in the U.S. had served as an overhang on the healthcare sector generally and had led to underperformance of healthcare stocks, including pharmaceuticals in late 2009 and early 2010. Whilst this situation was clarified with the enacting of the healthcare reform bill in March 2010, the significant gains made by the Republicans in the recent U.S. mid-term elections have again created uncertainty as to the nature of the reform. On a global basis, healthcare spending is set to continue to rise into 2011, and ageing populations, particularly in Western countries, will place increasing pressure on available government healthcare spending. Patent expiry continues to be an issue for the sector and the Company's portfolio has already been positioned to account for this and also for further consolidation in the sector. Our focus remains on the selection of stocks with strong prospects for capital enhancement and we continue to believe that the long term investor in our sector will be well rewarded. Martin Smith Chairman Interim Management Report Risks and Uncertainties A review of the half year, including reference to the risks and uncertainties that existed during the period, and the outlook for the Company can be found in the Chairman's Statement and the Review of Investments. The principal risks faced by the Company fall into nine broad categories: objective and strategy; level of discount/premium; market price and industry risk; liquidity risk; portfolio performance and financial instruments; operational and regulatory; credit risk; currency risk; and the risk associated with the Company's loan facility. Information on each of these areas is given in the Busine3ss review within the Annual report and accounts for the year ended 31 March 2010. In the view of the Board these principal risks and uncertainties are applicable to the remaining six months of the financial year as they were to the six months under review. Related Party Transactions During the first six months of the current financial year, no transactions with related parties have taken place which have affected the financial position or the performance of the Company during the period. Directors' Responsibilities The Directors are responsible for preparing the interim report in accordance with applicable law and regulations. The Directors confirm that to the best of their knowledge the condensed set of financial statements within the interim report, have been prepared in accordance with the Accounting Standards Board's Statement `Half Yearly Financial Reports' and that the Chairman's Statement and the Interim Management Report include a fair review of the information required by 4.2.7R and 4.2.8R of the FSA's Disclosure and Transparency Rules. The interim report has not been reviewed by the Company's auditors. The interim report was approved by the Board on 26 November and the above responsibility statement was signed on its behalf by: Martin Smith Chairman Review of Investments Performance For the period of 1 April to 30 September 2010, the broad markets demonstrated a roller coaster of performance, with a steep sell off in May, volatility in the summer months, before a significant, but only partial recovery in September. Despite such volatility in the global equity markets, the net result was only modestly negative, as the World Datastream Market Index was down 1.6% in sterling terms on a total return basis during this period. Moreover, healthcare stocks underperformed during the period; the Datastream Pharmaceutical & Biotechnology Index, measured in sterling terms on a total return basis, was down 3.6%. The Company outperformed both the broader market and the healthcare specific index, with a share price total return of -0.3% and a net asset value total return of +0.9%. "Alpha", or excess risk-adjusted returns, from this period stemmed from our strategy of being highly selective in large capitalisation pharmaceutical stocks, maintaining an overweight position in biotechnology stocks and adding exposure to several exciting niche growth opportunities in areas such as specialty and generic pharmaceutical companies. An example of such a niche opportunity is our investment in Japanese generic drug companies. Our long-term expectation of secular growth in this emerging generic drug market has been prescient as multiple government initiatives continue to drive accelerating growth for generic drugs in Japan. Sawai Pharmaceuticals based in Osaka, is one of three key investments in this theme, and was the largest contributor to performance during this six month period, largely due to better than expected sales and earnings which drove the share price. The company's share price suffered in September, however, on rumours of a takeover-bid for a branded manufacturer in Japan. We are cautious on this strategic initiative but believe the likelihood of it coming to fruition is low. Clarity on this issue should re-invigorate the shares. Also in the top ten contributors for the period were Towa Pharmaceutical and Nichi-iko Pharmaceutical, both Japanese generic drug manufactures benefitting from the dramatic growth of generic drugs in that market. In the large capitalisation pharmaceutical space, Novartis continues its unparalleled success in research and development (R&D) productivity with the recent approval of Gilenya, a novel oral therapy for the treatment of multiple sclerosis. We believe that this therapy will create an exciting new treatment option for this disease and represents one of the most important product approvals for the pharmaceutical industry in some while. We have also initiated a position in the originator of this compound, Mitsubishi Tanabe Pharma. Overall, we believe the market underestimates the opportunity offered by Gilenya to both Novartis and Mitsubishi Tanabe. The market enthusiasm generated by this drug propelled Novartis' shares by more than 10% during the period and thus was a top five contributor to performance. For now, the stock remains a key holding. Taking advantage of mergers and acquisition (M&A) activity in the biotechnology sector is a long held strategy of the Company. This period was exceptional for M&A, highlighted by the public offering by French drug maker, Sanofi-Aventis for Genzyme Corporation. The offer of $69 per share represented a 38% premium and was an all cash offer that totalled $18.5 billion. While a deal has yet to be agreed, at the time of writing this report, we believe there is a high probability that a transaction will occur at a higher price to be negotiated. Genzyme was the second highest contributor to performance during the period. It is also worth noting the contribution of our structured finance investments. Importantly, all of these investments have performed well to date, with no "losers" yet seen in the portfolio. The top two negative contributors during the period experienced losses that were (in whole or in part) triggered by the actions of the U.S. Food and Drug Administration (FDA). Roche, the Swiss pharmaceutical company, suffered a setback when an FDA panel recommended a partial revocation of the approval of the blockbuster cancer drug, Avastin, specifically for the treatment of metastatic breast cancer (mBC). While the earnings impact will be small (as Avastin would remain on the market for the treatment of other cancers), the negative recommendation caught investors by surprise, causing the stock to lose nearly $10 billion in market capitalisation, a steep over reaction, in our view. The FDA may be taking an overly conservative view on the data as the drug clearly benefits at least some patients with mBC. Adding to the negative news for Roche was the unusual and unexpected FDA "refusal to file" letter the company received for its novel next generation cancer compound known as TDM-1. Filing will now be predicated on additional studies that will not be complete until 2012. Finally, Roche also announced a pipeline setback for their emerging diabetes franchise. The culmination of these events resulted in the stock trading down more than 15% and thus claiming the designation of the portfolio's top negative contributor in the period. Roche, however, remains a core holding in the portfolio and we added to the position after the declines. Another disappointing holding during the period was the biotechnology company InterMune. The FDA failed to approve the company's novel treatment, Pirfenidone, for the treatment of a devastating and lethal disease known as idiopathic pulmonary fibrosis. InterMune was the second largest negative contributor to performance in the period. With a high likelihood for a requirement of additional expensive and time-consuming clinical trials to be conducted in order to garner U.S. approval, we exited the position. Sector Developments Clearly the largest development over the past six months has been the rippling impact of the passage of the Patient Protection and Affordable Care Act in the United States, which occurred in March 2010. We continue to believe this legislation to be a net positive for the healthcare sector and in particular the pharmaceutical industry. While near term earnings pressure certainly occurred at the margin for most pharmaceutical companies, long term the addition of 30 million new lives with healthcare insurance and drug coverage will be a boon to the industry. Importantly, this new law contains no provisions that will impose price controls or install the federal government as a major buyer of drugs, thus avoiding a worst case scenario for the healthcare industry. In fact, the term "reform" as applied to this legislation is misleading. Rather, this new law essentially expands the current federally-sponsored health insurance programmes, simply allowing more individuals to qualify. While pharmaceutical companies are required to help pay for this expansion through increased drug rebates, it is expected to cost the industry only $8 billion per year over 10 years (or $80 billion of the nearly $1 trillion total price tag). Note that U.S. pharmaceutical market reached over $300 billion in 2009. Thus, we believe that over time, the additional lives under coverage and the commensurate increase in drug consumption will more than offset any price or margin pressure. We think the defensive appeal of the sector has increased significantly with the removal of this overhang (i.e. uncertainty surrounding the timing and impact of healthcare reform) combined with growing concerns about slowing consumer spending in many developed markets. Healthcare goods and services are generally "non-discretionary" and should hold up relatively well in an era of frugal consumer spending Following on the political theme, the November 2010 mid-term elections in the U.S. saw the Democrats suffer heavy losses with the Republicans taking control of the House of Representatives and make significant gains in the Senate. This result brings uncertainty to the proposed healthcare reform as the Republicans have indicated that they would wish to `repeal and replace' the healthcare reform law passed earlier in the year. However, the polls suggest that, overall, the public wants the healthcare reform to be amended rather than scrapped altogether. The outcome is likely to remain unclear for some time. Finally, heading towards the end of 2010 and early 2011, we view the number of clinical trial related catalysts to be increasing. This growth is an encouraging sign of accelerating R&D and new product development for the sector. We will monitor carefully new clinical data flow in a plethora of therapeutic categories, in particular cardiovascular, diabetes, rheumatology, and oncology. Strategy Review An important change to highlight for our investors is that the Company's investment mandate has been expanded recently to include all areas of healthcare, including medical devices and healthcare services. This expansion is an exciting opportunity for OrbiMed to utilise a broader range of ideas and opportunities in pursuit of attractive returns for our investors. In addition to seeking higher returns, we also believe a more diversified portfolio will be less volatile. We had already begun repositioning the portfolio by the 30 September reporting date, with the additions of initial positions in Health Maintenance Organisations (so called "HMOs"), medical devices, and healthcare services companies. Valuation remains a compelling theme in the biotechnology and pharmaceutical sectors. In both absolute and relative terms, valuations have declined to historical lows after a nearly 10 year period of underperformance. We believe this performance and valuation differential provides a significant opportunity to earn near-term returns across a variety of companies. Despite the "bargains' in large capitalisation pharmaceutical companies, we continue to be selective in this sector although different strategies may be employed. Contrarian value plays with high yields are an option. Avoiding companies with extreme exposure to the looming 2012 generic patent cliff is another. Ultimately, however, we favour companies with new product flow and strong, late stage pipelines. Historically, companies entering such a new product cycle often outperform the group. This is, after all, an industry in which growth is driven by the launch of new drugs. Large capitalisation biotechnology companies remain a key focus. Growth in this sector is outpacing that of their pharmaceutical peers. Additionally, while new product risk may be higher in biotechnology companies, there is lower political and reimbursement risk. Finally, there are few patent expiration issues. Certainly we expect M&A in the sector to be robust and likely to accelerate as we approach 2012. Why? Pharmaceutical companies continue to prepare for the looming patent cliff and their urgency to solve the problem will increase as these patent expirations become more imminent. New products are the solution and acquiring them has proven easier than discovering them for large companies. Depressed valuations in small and mid-capitalisation biotechnology stocks create an opportunity for pharmaceutical companies to make such acquisitions, so we expect M&A deal volumes to increase and remain healthy. As such, we focus our investments in both high quality biotechnology and specialty pharmaceutical companies that may also be attractive to large potential acquirers. Samuel D Isaly OrbiMed Capital LLC Investment Manager Contribution by Investment - Excluding Options Top and bottom five contributors to net asset value performance over the six months to 30 September 2010 Contribution Contribution per Share (p)* for the six months £'000 Top Five contributors Sawai Pharmaceutical 2,752 6.3 Genzyme 2,539 5.8 NPS Pharmaceuticals 1,998 4.6 Endo Pharmaceuticals 1,764 4.1 Novartis 1,613 3.7 10,666 24.5 Bottom Five contributors Roche (4,792) (11.0) InterMune (2,646) (6.1) Johnson & Johnson (2,283) (5.2) Allos Therapeutics (1,844) (4.2) Gilead Sciences (1,817) (4.2) (13,382) (30.7) *based on the weighted average number of the Company's shares in issue during the six months ended 30 September 2010 (43,497,098) Source: Frostrow Capital LLP Portfolio as at 30 September 2010 Fair value % of Investment Portfolio Country £'000 investments Novartis Switzerland 32,028 8.0 Pfizer USA 27,404 6.9 Johnson & Johnson USA 24,370 6.1 Merck USA 23,704 5.9 Roche Switzerland 21,695 5.4 Bristol-Myers Squibb USA 17,549 4.4 Mitsubishi Tanabe Pharma Japan 10,331 2.6 Amgen USA 9,617 2.4 Endo Pharmaceuticals # USA 9,079 2.3 GlaxoSmithKline UK 8,593 2.1 Top 10 investments 184,370 46.1 Sinopharm China 8,503 2.1 Sanofi-Aventis France 8,256 2.1 Incyte ^ USA 8,107 2.0 Genzyme USA 7,886 2.0 Abbott Laboratories USA 7,851 2.0 Hospira USA 7,806 1.9 Sawai Pharmaceutical Japan 7,691 1.9 Dendreon ~ USA 7,296 1.8 Nichi-Iko Pharmaceutical Japan 7,045 1.8 Vertex Milestone Monetization (unquoted, CPEC)+ USA 7,040 1.8 Top 20 Investments 261,851 65.5 Shionogi Japan 6,670 1.7 Allergan USA 6,599 1.6 Shire Ireland 6,577 1.6 Towa Pharmaceutical Japan 6,427 1.6 Elan - USA 6,361 1.6 Biomarin Pharmaceutical USA 6,309 1.6 Warner Chilcott USA 6,052 1.5 Vertex Pharmaceuticals = USA 5,609 1.4 Gilead Sciences USA 5,559 1.4 Illumina USA 5,085 1.3 Top 30 Investments 323,099 80.8 Celgene USA 5,045 1.3 Lonza Switzerland 4,908 1.2 VWR Funding 10.25% 15/07/2015 USA 4,420 1.1 Aetna USA 3,811 1.0 NPS Pharmaceuticals USA 3,727 0.9 United Health USA 3,676 0.9 Wellpoint USA 3,591 0.9 Cubist Pharmaceuticals USA 3,456 0.9 Volcano ** USA 3,441 0.9 Human Genome Science USA 3,399 0.9 Top 40 Investments 362,573 90.8 Seattle Genetics USA 3,353 0.8 Zimmer USA 3,320 0.8 Align Technology USA 3,289 0.8 Momenta Pharmaceuticals USA 3,243 0.8 Angiotech Pharmaceuticals FRN 01/12/2013 USA 3,236 0.8 Pharma 10 Cinacalcet Royalty 15.5% 30/03/2017 USA 3,219 0.8 Biogen Idec USA 3,027 0.8 Allos Therapeutics USA 2,726 0.7 Actelion Switzerland 2,574 0.6 Carefusion USA 2,046 0.5 Total 50 Investments 392,606 98.2 QHP Royalty 10.25% 15/03/2015 USA 1,923 0.5 Savient Pharmaceuticals USA 1,812 0.5 Perrigo USA 1,630 0.4 King Pharmaceuticals USA 631 0.2 Given Imaging USA 43 0.0 Total Equities 398,645 99.8 Options - (Put & Call) 994 0.2 Total Investments including options 399,639 100.0 # includes Endo Pharmceuticals 1.75% 15/04/2015 equating to 0.5% of investments. ^ includes Incyte 4.75% 01/10/2015 convertible bond equating to 1.6% of investments. ~ includes Dendreon 4.75% 15/06/2014 convertible bond equating to 0.6% of investments. - includes Elan 8.75% 15/10/2016 equating to 0.6% of investments. = includes Vertex Pharmaceutical 3.35% 01/10/2015 equating to 0.7% of investments. ** includes Volcano 2.875% 01/09/2015 equating to 0.3% of investments. + Convertible Preferred Equity Certificates (CPEC) Income Statement For the six months ended 30 September 2010 (Unaudited) (Unaudited) (Audited) Six months ended Six months ended Year ended 30 September 2010 30 September 2009 31 March 2010 Revenue Capital Total Revenue Capital Total Revenue Capital Total Return Return Return Return Return Return Return Return Return £'000 £'000 £'000 £'000 £'000 £'000 £'000 £'000 £'000 (Losses)/gains on investments held at fair - (3,790) (3,790) - 15,192 15,192 - 76,180 76,180 value through profit or loss Exchange (losses)/gains on currency - (40) (40) - 5,516 5,516 - 3,946 3,946 balances Income from investments held at fair value through profit 3,059 - 3,059 1,886 - 1,886 5,825 - 5,825 or loss (note 2) Investment management, management and performance fees (note 3) (72) (3,264) (3,336) (60) (924) (984) (133) (5,025) (5,158) Other expenses (304) - (304) (261) (219) (480) (506) - (506) Net return/(loss) before finance 2,683 (7,094) (4,411) 1,565 19,565 21,130 5,186 75,101 80,287 charges and taxation Finance charges (4) (78) (82) (6) (121) (127) (11) (212) (223) Net return/(loss) 2,679 (7,172) (4,493) 1,559 19,444 21,003 5,175 74,889 80,064 before taxation Taxation on ordinary (483) 166 (317) (384) 168 (216) (965) 303 (662) activities Net return/(loss) 2,196 (7,006) (4,810) 1,175 19,612 20,787 4,210 75,192 79,402 after taxation Return/(loss) per share - 5.0p (16.1)p (11.1)p 2.8p 46.0p 48.8p 9.5p 170.5p 180.0p basic (note 4) Return/(loss) per share - 5.0p (16.1)p (11.1)p 2.8p 46.0p 48.8p 9.5p 170.5p 180.0p diluted (note 4) The "Total" column of this statement is the Income Statement of the Company. The "Revenue" and "Capital" columns are supplementary to this and are prepared under guidance published by the Association of Investment Companies. All revenue and capital items in the above statement derive from continuing operations. The Company has no recognised gains and losses other than those shown above and therefore no separate statement of total recognised gains and losses have been presented. No operations were acquired or discontinued during the period. Reconciliation of Movements in Shareholders' Funds Ordinary Subscription Share Capital (Unaudited) share share premium Capital redemption Revenue Six months ended capital capital account reserve reserve reserve Total 30 September 2010 £'000 £'000 £'000 £'000 £'000 £'000 £'000 At 31 March 2010 12,644 90 176,648 145,160 5,009 6,630 346,181 Net (loss)/return from ordinary activities after - - - (7,006) - 2,196 (4,810) taxation Dividend paid in respect of year ended 31 March - - - - - (3,653) (3,653) 2010 Subscription 172 (7) 4,045 7 - - 4,217 shares issued Purchase of Company's own shares including (1,969) - - (10,906) 1,969 - (10,906) expenses At 30 September 10,847 83 180,693 127,255 6,978 5,173 331,029 2010 Ordinary Share Capital (Unaudited) share premium Warrant Capital redemption Revenue Six months ended capital account reserve reserve reserve reserve Total 30 September 2009 £'000 £'000 £'000 £'000 £'000 £'000 £'000 At 31 March 2009 11,105 117,706 7,417 118,709 3,678 4,402 263,017 Net return from ordinary - - - 19,612 - 1,175 20,787 activities after taxation Dividends paid in respect of year ended 31 March - - - - - (1,982) (1,982) 2009 Proceeds from warrant exercise 2,686 54,590 (7,417) - - - 49,859 Subscription 97 (97) - - - - - shares issued Purchase of Company's own shares including (1,331) - - (22,360) 1,331 - (22,360) expenses At 30 September 12,557 172,199 - 115,961 5,009 3,595 309,321 2009 Reconciliation of Movements in Shareholders' Funds (Continued) (Audited) Ordinary Subscription Share Capital Year ended share share premium Warrant Capital redemption Revenue 31 March 2010 capital capital account reserve reserve reserve reserve Total £'000 £'000 £'000 £'000 £'000 £'000 £'000 £'000 At 31 March 11,105 - 117,706 7,417 118,709 3,678 4,402 263,017 2009 Net return on ordinary activities - - - - 75,192 - 4,210 79,402 after taxation Dividends paid in respect of year ended 31 March 2009 - - - - - - (1,982) (1,982) Proceeds from exercise of 2,686 - 47,174 - - - - 49,860 warrants Transfer from warrant reserve following - - 7,417 (7,417) - - - - exercise of warrants Subscription - 97 - - (295) - - (198) shares issued less issue costs Subscription 184 (7) 4,351 - 7 - - 4,535 shares exercised for ordinary shares Purchase of Company's own shares including (1,331) - - - (48,453) 1,331 - (48,453) expenses At 31 March 12,644 90 176,648 - 145,160 5,009 6,630 346,181 2010 Balance Sheet As at 30 September 2010 (Unaudited) (Unaudited) (Audited) 30 September 30 September 31 March 2010 2009 2010 £'000 £'000 £'000 Fixed assets Investments held at fair value through profit or loss 398,645 331,117 383,599 Current assets Debtors 1,251 793 1,757 Derivative - financial investments 994 1,315 628 2,245 2,108 2,385 Current liabilities Creditors: amounts falling due within (31,320) (8,143) (3,741) one year (38,541) (15,761) (36,062) Bank overdraft (69,861) (23,904) (39,803) Net current liabilities (67,616) (21,796) (37,418) Total net assets 331,029 309,321 346,181 Capital and reserves Ordinary share capital 10,847 12,557 12,644 Subscription share capital 83 - 90 Share premium account 180,693 172,199 176,648 Capital reserve 127,255 115,961 145,160 Capital redemption reserve 6,978 5,009 5,009 Revenue reserve 5,173 3,595 6,630 Total shareholders' funds 331,029 309,321 346,181 Net asset value per share - basic (note 763.0p 645.4p 780.8p 5) Net asset value per share - diluted 742.9p 640.1p 752.7p (note 5) Cash Flow Statement For the six months ended 30 September 2010 (Unaudited) (Unaudited) (Audited) Six months Six months Year ended ended ended 30 September 30 September 31 March 2010 2009 2010 £'000 £'000 £'000 Net cash inflow from operating 533 253 2,108 activities Servicing of finance Interest paid (82) (127) (223) Taxation Taxation recovered 182 169 93 Financial investment Purchases of investments and (116,763) (151,327) (265,795) derivatives Sales of investments and derivatives 124,037 135,054 250,859 Net cash inflow/(outflow) from financial investment 7,274 (16,273) (14,936) Equity dividends paid (3,653) (1,982) (1,982) Net cash inflow/(outflow) before 4,254 (17,960) (14,940) financing Financing Proceeds from exercise of warrants - 49,860 49,860 Subscription share issue costs - - (198) Purchase of own shares (10,910) (22,973) (49,061) Subscription shares exercised for ordinary shares 4,217 - 4,535 Net cash (outflow)/inflow from (6,693) 26,887 5,136 financing (Decrease)/increase in cash in the (2,439) 8,927 (9,804) period Reconciliation of net cash flow movements to net debt (Decrease)/increase in cash as above (2,439) 8,927 (9,804) Exchange movements (40) 5,516 3,946 Movement in net debt in the period (2,479) 14,443 (5,858) Net debt at beginning of period (36,062) (30,204) (30,204) Net debt at period end (38,541) (15,761) (36,062) Notes to the Financial Statements 1. Accounting Policies The condensed financial statements have been prepared under the historical cost convention, modified to include the valuation of investments at fair value and in accordance with United Kingdom Generally Accepted Accounting Practice and with the Statement of Recommended Practice `Financial Statements of Investment Trust Companies and Venture Capital Trusts' dated January 2009. All of the Company's operations are of a continuing nature. The same accounting policies used for the year ended 31 March 2010 have been applied. 2. Income (Unaudited) (Unaudited) (Audited) Six months ended Six months ended Year ended 30 September 30 September 31 March 2010 2009 2010 £'000 £'000 £'000 Investment income 2,407 1,517 5,763 Interest receivable 652 369 62 Total 3,059 1,886 5,825 3. Investment Management, Management and Performance Fees (Unaudited) (Unaudited) (Audited) Six months ended Six months ended Year ended 30 September 30 September 31 March 2010 2009 2010 £'000 £'000 £'000 Investment management fee 1,044 868 1,924 Management fee 397 340 730 Performance fee charged in the period/year* 1,895 (224) 2,759 Refund of VAT previously paid on management fees - - (255) Total 3,336 984 5,158 *In accordance with the performance fee arrangements described on page 18 of the 2010 annual report, a performance fee of £4,654,000 was accrued at 30 September 2010. In addition, during the period, £224,000 was paid which related to a performance fee which crystallised and became payable at 31 Match 2010. Notes to the Financial Statements (continued) 4. Return/(Loss) Per Share (Unaudited) (Unaudited) Six months Six months (Audited) ended 30 ended 30 Year ended September September 31 March 2010 2010 2009 £'000 £'000 £'000 The return/(loss) per share is based on the following figures: Revenue return 2,196 1,175 4,210 Capital (loss)/return (7,006) 19,612 75,192 Total (loss)/return (4,810) 20,787 79,402 Weighted average number of shares in issue for the period/year - 43,497,098 42,611,585 44,122,846 basic Revenue return per share 5.0p 2.8p 9.5p Capital (loss)/return per share (16.1)p 46.0p 170.5p Total (loss)/return per share (11.1)p 48.8p 180.0p Weighted average number of shares in issue for the period/year - 43,497,098 42,611,585 44,122,846 diluted Revenue return per share *5.0p *2.8p *9.5p Capital (loss)/return per share *(16.1)p *46.0p *170.5p Total (loss)/return per share - *(11.1)p *48.8p *180.0p diluted * dilution not applicable 5. Net Asset Value Per Share The net asset value per share is calculated on attributable assets at 30 September 2010 of £331,029,000 (30 September 2009: £309,321,000 and 31 March 2010: £346,181,000) and 43,385,916 being the number of shares in issue at 30 September 2010 (30 September 2009: 47,927,769 and 31 March 2010: 44,336,756). The diluted net asset value per share assumes all outstanding subscription shares were exercised at 638p per share resulting in assets attributable to equity shareholders of £384,018,000 and on 51,691,330 shares (30 September 2009: assumed all outstanding subscription shares were exercised at 614p per share resulting in assets attributable to equity shareholders of £369,069,000 and on 57,658,729 shares; March 2010: assumed all subscription shares were exercised at 614p per share resulting in assets attributable to equity shareholders of £401,394,000 and on 53,329,063 shares 6. Transaction Costs Purchase transaction costs for the six months ended 30 September 2010 were £319,000 (six months ended 30 September 2009: £237,000; year ended 31 March 2010: £467,000). Sales transaction costs for the six months ended 30 September 2010 were £229,000 (six months ended 30 September 2009: £214,000; year ended 31 March 2010: £372,000). These costs comprise mainly commission. Notes to the Financial Statements (continued) 7. Subscription Shares During the period ended 30 September 2010 a total of 686,893 subscription shares were exercised for a total consideration of £4,217,000. At the period end the Company's share capital included 8,305,414 subscription shares, which are currently exercisable at 638p per share. 8. Publication of Non Statutory Accounts The financial information contained in this preliminary announcement does not constitute statutory accounts as defined in sections 434-436 of the Companies Act 2006. The financial information for the half years ended 30 September 2010 and 30 September 2009 has not been audited or reviewed by the auditors. The information for the year ended 31 March 2010 has been extracted from the latest published audited financial statements. The audited financial statements for the year ended 31 March 2010 have been filed with the Registrar of Companies. The report of the auditors on those accounts was unqualified, did not include a reference to any matters to which the auditors drew attention by way of emphasis without qualifying the report, and did not contain statements under section 498 of the Companies Act 2006. Earnings for the first six months should not be taken as a guide to the results for the full year. Alliance Trust Savings Limited The Company's shares are available through savings plans (including investment Dealing Accounts, ISAs and SIPPs) operated by Alliance Trust Savings Limited, which facilitates both regular monthly investments and lump sum investments in the Company's shares. Shareholders who would like information on the savings plans should call Alliance Trust Savings Limited on 01382 573737 or log on to www.alliancetrust.co.uk/alliancetrustsavings/ or email contact@alliancetrust.co.uk. Calls to this number may be recorded for monitoring purposes. An Individual Savings Account (`ISA') is a tax efficient method of investment for an individual which gives the opportunity to invest in the Company up to £10,200 in the tax year 2010/2011 and in subsequent tax years when they subscribe to a Stocks and Shares ISA. The preceding two paragraphs have been issued and approved by Alliance Trust Savings Limited. Alliance Trust Savings Limited of PO Box 164, 8 West Marketgait, Dundee DD1 9YP is registered in Scotland with number SC98767. Alliance Trust Savings Limited provides investment products and services and is authorised and regulated by the Finance Services Authority. It does not provide investment advice. Capita Registrars - Share Dealing Service A quick and easy share dealing service is available to existing shareholders through the Company's Registrar, Capita Registrars, to either buy or sell shares. An online and telephone dealing facility provides an easy to access and simple to use service. Type of trade Online Telephone Share certificates 1% of the value of the deal 1.5% of the value of the deal (Minimum £20.00, max £75.00) (Minimum £25.00, max £102.50) There is no need to pre-register and there are no complicated forms to fill in. The online and telephone dealing service allows you to trade `real time' at a known price which will be given to you at the time you give your instruction. To deal online or by telephone all you need is your surname, shareholder reference number, full postcode and your date of birth. Your shareholder reference number can be found on your latest statement or certificate where it will appear as either a `folio number' or `investor code'. Please have the appropriate documents to hand when you log on or call, as this information will be needed before you can buy or sell shares. For further information on this service please contact: www.capitadeal.com (online dealing) or 0871 664 0445† (telephone dealing) †Calls cost 10p per minute plus network extras and may be recorded for training purposes. Lines are open from 8.30 a.m. to 4.30 p.m. Monday to Friday. The Share Dealing Service is provided by Capita IRG Trustees Limited which has issued and approved the preceding paragraphs. Capita IRG Trustees Limited, The Registry, 34 Beckenham Road, Beckenham, Kent BR3 4TU is registered in England and Wales with number 2729260. Capita IRG Trustees Limited is authorised and regulated by the Financial Services Authority. Risk Warnings - Past performance is no guarantee of future performance. - The value of your investment and any income from it may go down as well as up and you may not get back the amount invested. This is because the share price is determined by the changing conditions in the relevant stockmarkets in which the Company invests and by the supply and demand for the Company's shares. - As the shares in an investment trust are traded on a stockmarket, the share price will fluctuate in accordance with supply and demand and may not reflect the underlying net asset value of the shares; where the share price is less than the underlying value of the assets, the difference is known as the `discount'. For these reasons, investors may not get back the original amount invested. - Although the Company's financial statements are denominated in sterling, it may invest in stocks and shares that are denominated in currencies other than sterling and to the extent they do so, they may be affected by movements in exchange rates. As a result, the value of your investment may rise or fall with movements in exchange rates. - Investors should note that tax rates and reliefs may change at any time in the future. - The value of ISA tax advantages will depend on personal circumstances. The favourable tax treatment of ISAs may not be maintained. Company Information Directors John Sclater CVO, (Chairman) Sven Borho Paul Gaunt Dr John Gordon Peter Keen Lord Waldegrave of North Hill Company Registration Number 3376377 (Registered in England) The Company is an investment company as defined under Section 833 of the Companies Act 2006. Registered Office One Wood Street, London EC2V 7WS Website: www.biotechgt.com Investment Manager OrbiMed Capital LLC 767 Third Avenue, 30th Floor, New York NY10017-2023 USA Telephone: +1 212-739-6400 www.orbimed.com Registered under the U.S. Securities Exchange Commission. Manager, Administrator and Company Secretary Frostrow Capital LLP 25 Southampton Buildings, London WC2A 1AL Telephone: 0203 008 4910 E-Mail: info@frostrow.com Website: www.frostrow.com Authorised and regulated by the Financial Services Authority. If you have an enquiry about the Company or if you would like to receive a copy of the Company's monthly fact sheet by e-mail, please contact Frostrow Capital using the above e-mail address. Custodian and Banker Goldman Sachs & Co. 200 West Street, Third Floor New York NY10282 Auditors Grant Thornton UK LLP 30 Finsbury Square, London EC2P 2YU Stockbrokers Winterflood Investment Trusts The Atrium Building, Cannon Bridge, 25 Dowgate Hill, London EC4R 2GA Registrars Capita Registrars Northern House, Woodsome Park, Fenay Bridge, Huddersfield, West Yorkshire HD8 0LA Telephone (in UK): 0871 664 0300† Telephone (from overseas): +44 208 639 3399 Facsimile: +44 (0) 1484 600911 E-Mail: ssd@capitaregistrars.com Website: www.capitaregistrars.com Please contact the Registrars if you have a query about a certificated holding in the Company's shares. †Calls cost 10p per minute plus network extras and may be recorded for training purposes. Lines are open from 8.30 a.m.-5.30 p.m. Monday-Friday. Share Price Listings The price of your shares can be found in various publications including the Financial Times, The Daily Telegraph, The Times, The Scotsman and The Herald. The Company's net asset value per share is announced daily on the TrustNet website at www.trustnet.com Identification Codes Shares:SEDOL:0038551 ISIN:GB0000385517 BLOOMBERG:BIOG LN Epic: BIOG Enquiries: Mark Pope - Tel: 0203 008 4913 Frostrow Capital LLP 25 Southampton Buildings London WC2A AL 30 November 2009 END
UK 100

Latest directors dealings