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GlaxoSmithKline PLC (GSK)

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Thursday 26 October, 2006

GlaxoSmithKline PLC

Director/PDMR Shareholding

GlaxoSmithKline PLC
26 October 2006

   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

24 October 2006  Abacus (GSK) Trustees Limited, as trustee of the
                 GlaxoSmithKline Employee Trust, ("the GSK Trust"), sold 2,849
                 Ordinary Shares in the Company on behalf of participants in the
                 GlaxoSmithKline Share Value Plan at a price of £14.88 per
                 share.

                 The GSK Trust transferred 9,805 Ordinary Shares to participants
                 in the GlaxoSmithKline Share Value Plan.

                 The GSK Trust transferred 82,731 Ordinary Shares in the Company
                 to participants in the SmithKline Beecham Employee Share Option
                 Plan 1991.

The Company was advised of these transactions on 25 October 2006.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr M M Slaoui
and Mr J S Heslop are therefore interested in the shares held in the GSK Trust
from time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).

S M Bicknell
Company Secretary

26 October 2006


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