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AstraZeneca PLC (AZN)

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Friday 22 September, 2006

AstraZeneca PLC

Director/PDMR Shareholding

AstraZeneca PLC
22 September 2006

Dealing by Directors
Companies Act 1985 Sections 324/329

We hereby inform you that on 21 September 2006 Mr John Varley, a Director of the
Company, purchased 500 AstraZeneca PLC USD0.25 Ordinary Shares at a price of
3346 pence per share.

This represents Mr Varley's total interest, which is approximately 0.00003% of
the issued ordinary capital of the Company.

G H R Musker
Company Secretary
22 September 2006


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