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Protherics PLC (PTI)

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Friday 08 April, 2005

Protherics PLC

Director Shareholding

Protherics PLC
8 April 2005


                                     SCHEDULE 11

                  NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED 
                                       PERSONS


1)   NAME OF COMPANY

     PROTHERICS PLC

2)   NAME OF DIRECTOR

     JAMES CAMPBELL CHRISTIE

3)   Please state whether notification indicates that it is in respect of
     holding of the shareholder named in 2 above or in respect of a
     non-beneficial interest or in the case of an individual holder
     if it is a holding of that person's spouse or children under the
     age of 18 or in respect of an non-beneficial interest

     AS NAMED IN 2 ABOVE

4)   Name of the registered holder(s) and, if more than one holder, the
     number of shares held by each of them. (If notified)

     JAMES CAMPBELL CHRISTIE

5)   Please state whether notification relates to a person(s) connected
     with the Director named in 2 above and identify the connected person(s)

     N/A

6)   Please state the nature of the transaction. For PEP transactions
     please indicate whether general/single co PEP and if discretionary/non
     discretionary

     EXERCISE OF OPTIONS IN APPROVED SAVINGS-RELATED SCHEME

7)   Number of shares/amount of
     stock acquired

     27,000

8)   Percentage of issued Class (any treasury shares held by company should not
     be taken into account when calculating percentage)

     0.01%

9)   Number of shares/amount
     of stock disposed

     

10)  Percentage of issued Class (any treasury shares held by company should not
     be taken into account when calculating percentage)



11)  Class of security

     2p ORDINARY SHARES

12)  Price per share

     37.5 PENCE

13)  Date of transaction

     6th APRIL 2005

14)  Date company informed

     6th APRIL 2005

15)  Total holding following this notification

     28,343 2P ORDINARY SHARES

16)  Total percentage holding of issued class following this notification (any 
     treasury shares held by company should not be taken into account when 
     calculating percentage)

     0.01%

     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17)  Date of grant



18)  Period during which or date on which exercisable



19)  Total amount paid (if any) for grant of the option



20)  Description of shares or debentures involved: class, number.



21)  Exercise price (if fixed at time of grant) or indication that price
     is to be fixed at time of exercise



22)  Total number of shares or debentures over which options held
     following this notification



23)  Any additional information



24)  Name of contact and telephone number for queries



25)  Name and signature of authorised company official responsible for
     making this notification

     B.M. Riley

     Date of Notification      8th April 2005                           



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