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Pharmagene PLC (PGN)

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Wednesday 31 March, 2004

Pharmagene PLC

Director Shareholding

Pharmagene PLC
31 March 2004

                         PHARMAGENE PLC ('The Company')

                             Director Shareholdings

31 March 2004: The Company was notified today by Ron Long that he has today
purchased 32,786 ordinary shares of 5p each in the Company, at a price of 61p
per share. Following this purchase, Mr Long's total holding in Pharmagene plc
amounts to 32,786 ordinary shares, representing 0.06% of the Company's
outstanding shares.

The Company was also notified today by Dr Robert Coleman that he has today
exercised 60,000 share options over ordinary shares with a par value of 5p each.
The exercise price of these share options was 9.5p each and the options were due
to expire on 30 June 2004. Dr Coleman has sold 29,953 shares in order to meet
his financial commitments in terms of exercise price, tax and costs associated
with the transaction. Following the transactions, Dr Coleman holds a total of
878,380 ordinary shares representing 1.65% of the Company's outstanding shares.


For further details please contact:

Pharmagene plc                                    
Alastair Riddell, CEO                                       01763 211602
Neil Johnston, CFO
Financial Dynamics
Francetta Carr/David Yates                                  020 7831 3113

                      This information is provided by RNS
            The company news service from the London Stock Exchange